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Hemangiosarcoma; Malignant hemangioendothelioma
Angiosarcoma (AS) is a malignant tumor of endothelial cells.
AS of the urogenital tract is very rare, with most studies consisting of single case reports. A weak association with previous radiotherapy has been reported.
It occurs in adult and elderly patients.
AS of the kidney occurs more frequently in males than females (M:F = 7:1).
Urogenital angiosarcomas arise more frequently in the kidney and prostate. Rare cases have been described in the ureter, the bladder, the epididymis, and the penis.
Surgery is the primary treatment, with radiotherapy and chemotherapy employed in approximately 30% of the patients.
AS is a high-grade tumor with frequent local relapse and lymph node and distant metastases. The lungs and liver are the most common sites of metastasis.
Grossly, the tumor presents as an ill-defined, invasive hemorrhagic mass often with areas of...
References and Further Reading
- Brown, J. G., Folpe, A. L., Rao, P., Lazar, A. J., Paner, G. P., Gupta, R., Parakh, R., Cheville, J. C., & Amin, M. B. (2010). Primary vascular tumors and tumor-like lesions of the kidney: A clinicopathologic analysis of 25 cases. The American Journal of Surgical Pathology, 34, 942–949.CrossRefGoogle Scholar
- Gogoi, D., Hazra, S., Ghosh, B., & Pal, D. (2013). Angiosarcoma of penis. BML Case Reports, 2013. pii: bcr2013200878.Google Scholar
- Seethala, R. R., Gomez, J. A., & Vakar-Lopez, F. (2006). Primary angiosarcoma of the bladder. Archives of Pathology & Laboratory Medicine, 130, 1543–1547.Google Scholar