Definition
A renal tumor with variable morphological patterns arising exclusively in end-stage kidneys with acquired cystic disease.
Clinical Features
Incidence
These tumors occur most often, but not always, in patients undergoing long-term hemodialysis with acquired cystic disease and are usually incidental finding detected during their follow-up. Often they are multiple and bilateral. It represents roughly one third of all renal cell neoplasms arising in end-stage renal disease.
Age
It frequently occurs in patients receiving hemodialysis of more than 10 years
Sex
There is no gender predilection.
Site
There is no site predilection.
Treatment
Surgical treatment is recommended.
Outcome
Because of early detection of tumors in patients on periodical follow-up imaging analyses for chronic renal failure, the clinical behavior is usually indolent.
Macroscopy
The tumor is well circumscribed and tan to yellow in color with occasional hemorrhage or necrosis occurring in a background of multiple...
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References and Further Reading
Cossu-Rocca, P., Eble, J. N., Zhang, S., Martignoni, G., Brunelli, M., & Cheng, L. (2006). Acquired cystic disease-associated renal tumors: An immunohistochemical and fluorescence in situ hybridization study. Modern Pathology, 19, 780–787.
Kuroda, N., Tamura, M., Hamaguchi, N., Mikami, S., Pan, C. C., Brunelli, M., Martignoni, G., Hes, O., Michal, M., & Lee, G. H. (2011). Acquired cystic disease–associated renal cell carcinoma with sarcomatoid change and rhabdoid features. Annals of Diagnostic Pathology, 15(6), 462–466.
Pan, C. C., Chen, Y. J., Chang, L. C., Chang, Y. H., & Ho, D. M. (2009). Immunohistochemical and molecular genetic profiling of acquired cystic disease-associated renal cell carcinoma. Histopathology, 55, 145–153.
Tickoo, S. K., deParalta-Venturia, M. N., Harik, L. R., Worcester, H. D., Salama, M. E., Young, A. N., Moch, H., & Amin, M. B. (2006). Spectrum of epithelial neoplasms in end-stage renal disease: An experience from 66 tumor-bearing kidneys with emphasis on histologic patterns distinct from those in sporadic adult renal neoplasia. The American Journal of Surgical Pathology, 30(2), 141–153.
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Caliò, A., Segala, D., Martignoni, G. (2020). Acquired Cystic Disease-Associated Renal Cell Carcinoma. In: Raspollini, M.R., Lopez-Beltran, A. (eds) Uropathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-41894-6_4775
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DOI: https://doi.org/10.1007/978-3-030-41894-6_4775
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