2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran


  • Anna Caliò
  • Diego Segala
  • Guido MartignoniEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_3804


Oncocytoma is a benign renal cell tumor with mainly solid-nested architecture composed of predominantly large eosinophilic cells packed with mitochondria.

Clinical Features

Oncocytomas are sporadic tumors; cases in association with Birt-Hogg-Dubé (an autosomal dominant disease associated with mutation of the folliculin gene) have been reported.

A group of patients with multiple oncocytic lesions called oncocytosis has been described. Some of these lesions have a hybrid morphology between oncocytoma and chromophobe renal cell carcinoma, suggesting that these neoplasms can be related.
  • Incidence

    They comprise 5% of adult renal epithelial tumors in surgical series.

  • Age

    The peak incidence is in the seventh decade of life.

  • Sex

    Its male-to-female ratio is 2:1.

  • Site

    There is no prevalence of site.

  • Treatment

    Partial or radical nephrectomy, based on the tumor size, is the standard. In selected cases, active surveillance may be an option.

  • Outcome

    Renal oncocytomas are benign neoplasms.

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References and Further Reading

  1. Brunelli, M., Delahunt, B., Gobbo, S., Tardanico, R., Eccher, A., Bersani, S., Cossu-Rocca, P., Parolini, C., Balzarini, P., Menestrina, F., Cheng, L., Eble, J. N., & Martignoni, G. (2010). Diagnostic usefulness of fluorescent cytogenetics in differentiating chromophobe renal cell carcinoma from renal oncocytoma: A validation study combining metaphase and interphase analyses. American Journal of Clinical Pathology, 133(1), 116–126.CrossRefGoogle Scholar
  2. Klein, M. J., & Valensi, Q. J. (1976). Proximal tubular adenomas of kidney with so-called oncocytic features. A clinicopathologic study of 13 cases of a rarely reported neoplasm. Cancer, 38(2), 906–914.CrossRefGoogle Scholar
  3. Perez-Ordonez, B., Hamed, G., Campbell, S., Erlandson, R. A., Russo, P., Gaudin, P. B., & Reuter, V. E. (1997). Renal oncocytoma: A clinicopathologic study of 70 cases. The American Journal of Surgical Pathology, 21(8), 871–883.CrossRefGoogle Scholar
  4. Rocca, P. C., Brunelli, M., Gobbo, S., Eccher, A., Bragantini, E., Mina, M. M., Ficarra, V., Zattoni, F., Zamò, A., Pea, M., Scarpa, A., Chilosi, M., Menestrina, F., Bonetti, F., Eble, J. N., & Martignoni, G. (2007). Diagnostic utility of S100A1 expression in renal cell neoplasms: An immunohistochemical and quantitative RT-PCR study. Modern Pathology, 20(7), 722–728.CrossRefGoogle Scholar
  5. Trpkov, K., Yilmaz, A., Uzer, D., Dishongh, K. M., Quick, C. M., Bismar, T. A., & Gokden, N. (2010). Renal oncocytoma revisited: A clinicopathological study of 109 cases with emphasis on problematic diagnostic features. Histopathology, 57(6), 893–906.CrossRefGoogle Scholar

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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Diagnostic and Public Health, Section of PathologyUniversity of VeronaVeronaItaly
  2. 2.Department of PathologyPederzoli HospitalPeschiera del GardaItaly