Uropathology

2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Seminoma

  • Maurizio ColecchiaEmail author
  • Alessia Bertolotti
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_3796
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Synonyms

Germinoma

Definition

A malignant germ cell tumor morphologically represented by cells similar to primordial germ cells/gonocytes.

Clinical Features

  • Incidence

    Seminoma comprises 40–50% of all GCTs. About 10% of seminoma patients have a history of criptorchidism and higher proportions have been noted in patients with immunodeficiency disorders.

  • Age

    It occurs commonly between the age of 25–50, with a peak incidence at about 34 years. Seminoma is virtually nonexistent before puberty and it is rare in adolescence (1%) with the exception of children who have a disorder of sex development; seminoma is rare in men older than 70 years (Berney et al. 2008).

  • Site

    Most patients present with a testicular mass, while 3% of seminomas present with symptoms related to metastatic localization as lower back pain caused by retroperitoneal lymphnode involvement. Other lymphnodal metastases could occur to the mediastinal and cervical lymphnodes; visceral metastases typically occur in the liver and...

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References and Further Reading

  1. Berney, D. M., Warren, A. Y., Verma, M., Kudahetti, S., Robson, J. M., Williams, M. W., Neal, D. E., Powles, T., Shamash, J., & Oliver, R. T. (2008). Malignant germ cell tumours in the elderly: A histopathological review of 50 cases in men aged 60 years or over. Modern Pathology, 21(1), 54–59.PubMedCrossRefGoogle Scholar
  2. Cheville, J. C., Rao, S., Iczkowski, K. A., Lohse, C. M., & Pankratz, V. S. (2000). Cytokeratin expression in seminoma of the human testis. The American Journal of Clinical Pathology, 113(4), 583–588.PubMedCrossRefGoogle Scholar
  3. Henley, J. D., Young, R. H., Wade, C. L., & Ulbright, T. M. (2004). Seminomas with exclusive intertubular growth: A report of 12 clinically and grossly inconspicuous tumors. The American Journal of Surgical Pathology, 28(9), 1163–1168.PubMedCrossRefGoogle Scholar
  4. Ulbright, T. M., & Young, R. H. (2005). Seminoma with tubular, microcystic, and related patterns: A study of 28 cases of unusual morphologic variants that often cause confusion with yolk sac tumor. The American Journal of Surgical Pathology, 29(4), 500–505.PubMedCrossRefGoogle Scholar
  5. Ye, H., & Ulbright, T. M. (2012). Difficult differential diagnoses in testicular pathology. Archives of Pathology & Laboratory Medicine, 136(4), 435–446.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Uropathology Unit, Department of PathologyFondazione IRCCS Istituto Nazionale dei Tumori di MilanoMilanItaly
  2. 2.Department of PathologyFondazione IRCCS Istituto Nazionale dei Tumori di MilanoMilanItaly