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Angiomyolipoma is the most common mesenchymal neoplasm of the kidney, classically composed by a variable mixture of adipocytes, smooth muscle cells, and abnormal thick-wall blood vessels. The perivascular epithelioid cell is considered to be the cell of origin for this and other related tumors.
Angiomyolipoma accounts for approximately 1% of surgically removed renal tumors.
Sporadic angiomyolipoma occurs in the fourth to sixth decades of life, whereas tuberous sclerosis in the third and fourth decades of life.
Sporadic angiomyolipoma has a female predominance; in patients with tuberous sclerosis, there is no gender predilection.
There is no site predilection in the sporadic angiomyolipoma, whereas those occurring in patients with tuberous sclerosis are usually bilateral, small, and multifocal.