Synonyms
Nephrogenic metaplasia
Definition
Metaplastic change characterized by small tubules lined by a single layer of cuboidal, flat, or hobnail cells containing eosinophilic secretion with features similar to mesonephric tubules.
Clinical Features
Incidence
This is an uncommon lesion. Most patients have a previous bladder surgery or irritants such calculi or trauma, or kidney transplantation.
Age
Usually seen in adults but rare in children
Sex
Male: female: 3:1
Site
The bladder is the most common (55%) followed by urethra (41%) or ureter (4%).
Treatment
Resection
Outcome
Benign outcome
Macroscopy
These are less than 1 cm polypoid, flat, or papillary lesions. Large size examples have been reported.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References and Further Reading
McDaniel, A. S., Chinnaiyan, A. M., Siddiqui, J., et al. (2014). Immunohistochemical staining characteristics of nephrogenic adenoma using the PIN-4 cocktail (p63. AMACR, and CK903) and GATA3. The American Journal of Surgical Pathology, 38, 1664–1671.
Oliva, E., & Young, R. H. (1995). Nephrogenic adenoma of the urinary tract: A review of the microscopic appearance of 80 cases with emphasis on unusual features. Modern Pathology, 8, 722–730.
Tong, G. X., Weeden, E. M., Hamele-Bena, D., et al. (2008). Expression of PAX8 in nephrogenic adenoma and clear cell adenocarcinoma of the lower urinary tract: Evidence of related histogenesis? The American Journal of Surgical Pathology, 32, 1380–1387.
Zhang, G., McDaniel, A. S., Mehra, R., & McKenney, J. K. (2017). Nephrogenic adenoma does not express NKX3.1. Histopathology, 71, 669–671.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this entry
Cite this entry
Raspollini, M.R., Lopez-Beltran, A. (2020). Nephrogenic Adenoma. In: Raspollini, M.R., Lopez-Beltran, A. (eds) Uropathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-41894-6_3763
Download citation
DOI: https://doi.org/10.1007/978-3-030-41894-6_3763
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-41893-9
Online ISBN: 978-3-030-41894-6
eBook Packages: MedicineReference Module Medicine