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Sertoli Cell Tumor

  • Reference work entry
  • First Online:
Uropathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 15 Accesses

Synonyms

Androblastoma

Definition

Sertoli cell tumor (SCT) is a tumor of the gonadal stroma; it is composed of cells resembling embryonal, prepubertal, and adult Sertoli cells.

Clinical Features

  • Incidence

    SCT accounts for <1% of all testicular tumors, yet it is the second most common sex cord–stromal tumor.

  • Age

    SCT occurs in a wide range of age, most occurring in adults.

  • Sex

    Male.

  • Site

    Testis.

  • Treatment

    Orchiectomy remains the only therapeutic option, because radiotherapy and chemotherapy have been unsuccessful to date.

  • Outcome

    About 12% of SCTs are malignant; malignant cases have also been reported in children (Young et al. 1998). Gynecomastia seems to be more frequent in malignant cases. Features predictive of aggressive behavior include extratesticular spread, size >5 cm, high-grade cytological atypia, > 5 mitoses per 10/HPFs, and necrosis and lymphovascular invasion. The distribution of organ metastases, as in malignant Leydig tumors, involves retroperitoneal lymph nodes and, when...

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References and Further Reading

  • Divatia, M., Smith, S., Colecchia, M., Aron, M., Amin, M., Shen, S. S., Hansel, D., Tamboli, P., Paner, G. P., de Peralta-Venturina, M., Herrera Hernandez, L., & Gowen, A. M. (2015). Diagnostic utility of comprehensive immunohistochemical (IHC) panel for testicular sexcord stromal tumors (TSCST): A study of 76 cases. USCAP 2015. Abstract book. Abstract 860, p. 216A.

    Google Scholar 

  • Kao, C. S., Kum, J. B., Idrees, M. T., & Ulbright, T. M. (2014). Sclerosing Sertoli cell tumor of the testis: A clinicopathologic study of 20 cases. The American Journal of Surgical Pathology, 38(4), 510–517.

    Article  PubMed  Google Scholar 

  • Perrone, F., Bertolotti, A., Montemurro, G., Paolini, B., Pierotti, M. A., & Colecchia, M. (2014). Frequent mutation and nuclear localization of β-catenin in sertoli cell tumors of the testis. The American Journal of Surgical Pathology, 38(1), 66–71.

    Article  PubMed  Google Scholar 

  • Young, R. H., Koelliker, D. D., & Scully, R. E. (1998). Sertoli cell tumors of the testis, not otherwise specified: A clinicopathologic analysis of 60 cases. The American Journal of Surgical Pathology, 22(6), 709–721.

    Article  CAS  PubMed  Google Scholar 

  • Zukerberg, L. R., Young, R. H., & Scully, R. E. (1991). Sclerosing Sertoli cell tumor of the testis. A report of 10 cases. The American Journal of Surgical Pathology, 15(9), 829–834.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Uropathology Unit, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

    Maurizio Colecchia

  2. Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

    Alessia Bertolotti

Authors
  1. Maurizio Colecchia
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  2. Alessia Bertolotti
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Corresponding author

Correspondence to Maurizio Colecchia .

Editor information

Editors and Affiliations

  1. Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy

    Maria Rosaria Raspollini

  2. Pathology Service, Champalimaud Clinical Center, Lisbon, Portugal

    Antonio Lopez-Beltran

  3. Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain

    Antonio Lopez-Beltran

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Cite this entry

Colecchia, M., Bertolotti, A. (2020). Sertoli Cell Tumor. In: Raspollini, M.R., Lopez-Beltran, A. (eds) Uropathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-41894-6_3755

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  • DOI: https://doi.org/10.1007/978-3-030-41894-6_3755

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-41893-9

  • Online ISBN: 978-3-030-41894-6

  • eBook Packages: MedicineReference Module Medicine

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