Sertoli Cell Tumor
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Sertoli cell tumor (SCT) is a tumor of the gonadal stroma; it is composed of cells resembling embryonal, prepubertal, and adult Sertoli cells.
SCT accounts for <1% of all testicular tumors, yet it is the second most common sex cord–stromal tumor.
SCT occurs in a wide range of age, most occurring in adults.
Orchiectomy remains the only therapeutic option, because radiotherapy and chemotherapy have been unsuccessful to date.
About 12% of SCTs are malignant; malignant cases have also been reported in children (Young et al. 1998). Gynecomastia seems to be more frequent in malignant cases. Features predictive of aggressive behavior include extratesticular spread, size >5 cm, high-grade cytological atypia, > 5 mitoses per 10/HPFs, and necrosis and lymphovascular invasion. The distribution of organ metastases, as in malignant Leydig tumors, involves retroperitoneal lymph nodes and, when...
References and Further Reading
- Divatia, M., Smith, S., Colecchia, M., Aron, M., Amin, M., Shen, S. S., Hansel, D., Tamboli, P., Paner, G. P., de Peralta-Venturina, M., Herrera Hernandez, L., & Gowen, A. M. (2015). Diagnostic utility of comprehensive immunohistochemical (IHC) panel for testicular sexcord stromal tumors (TSCST): A study of 76 cases. USCAP 2015. Abstract book. Abstract 860, p. 216A.Google Scholar