Uropathology

2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Sertoli Cell Tumor

  • Maurizio ColecchiaEmail author
  • Alessia Bertolotti
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_3755
  • 3 Downloads

Synonyms

Androblastoma

Definition

Sertoli cell tumor (SCT) is a tumor of the gonadal stroma; it is composed of cells resembling embryonal, prepubertal, and adult Sertoli cells.

Clinical Features

  • Incidence

    SCT accounts for <1% of all testicular tumors, yet it is the second most common sex cord–stromal tumor.

  • Age

    SCT occurs in a wide range of age, most occurring in adults.

  • Sex

    Male.

  • Site

    Testis.

  • Treatment

    Orchiectomy remains the only therapeutic option, because radiotherapy and chemotherapy have been unsuccessful to date.

  • Outcome

    About 12% of SCTs are malignant; malignant cases have also been reported in children (Young et al. 1998). Gynecomastia seems to be more frequent in malignant cases. Features predictive of aggressive behavior include extratesticular spread, size >5 cm, high-grade cytological atypia, > 5 mitoses per 10/HPFs, and necrosis and lymphovascular invasion. The distribution of organ metastases, as in malignant Leydig tumors, involves retroperitoneal lymph nodes and, when...

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References and Further Reading

  1. Divatia, M., Smith, S., Colecchia, M., Aron, M., Amin, M., Shen, S. S., Hansel, D., Tamboli, P., Paner, G. P., de Peralta-Venturina, M., Herrera Hernandez, L., & Gowen, A. M. (2015). Diagnostic utility of comprehensive immunohistochemical (IHC) panel for testicular sexcord stromal tumors (TSCST): A study of 76 cases. USCAP 2015. Abstract book. Abstract 860, p. 216A.Google Scholar
  2. Kao, C. S., Kum, J. B., Idrees, M. T., & Ulbright, T. M. (2014). Sclerosing Sertoli cell tumor of the testis: A clinicopathologic study of 20 cases. The American Journal of Surgical Pathology, 38(4), 510–517.PubMedCrossRefGoogle Scholar
  3. Perrone, F., Bertolotti, A., Montemurro, G., Paolini, B., Pierotti, M. A., & Colecchia, M. (2014). Frequent mutation and nuclear localization of β-catenin in sertoli cell tumors of the testis. The American Journal of Surgical Pathology, 38(1), 66–71.PubMedCrossRefGoogle Scholar
  4. Young, R. H., Koelliker, D. D., & Scully, R. E. (1998). Sertoli cell tumors of the testis, not otherwise specified: A clinicopathologic analysis of 60 cases. The American Journal of Surgical Pathology, 22(6), 709–721.PubMedCrossRefGoogle Scholar
  5. Zukerberg, L. R., Young, R. H., & Scully, R. E. (1991). Sclerosing Sertoli cell tumor of the testis. A report of 10 cases. The American Journal of Surgical Pathology, 15(9), 829–834.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Uropathology Unit, Department of PathologyFondazione IRCCS Istituto Nazionale dei Tumori di MilanoMilanItaly
  2. 2.Department of PathologyFondazione IRCCS Istituto Nazionale dei Tumori di MilanoMilanItaly