Living reference work entry
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Analgesics interfere with the generation and/or transmission of impulses following noxious stimulation (nociception) in the nervous system. This can occur at peripheral and/or central levels of the neuraxis. The therapeutic aim is to diminish the perception of pain.
Nonsteroidal Anti-inflammatory Drugs
Mechanisms of Action
Analgesics aim at modulating the generation of noxious chemicals (e.g., prostaglandins) or the activation of neuronal receptors/ion channels transducing/transmitting noxious stimuli (e.g., peptide receptors, Ca ++ channels). Clinically used drugs include opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), antiepileptics, and antidepressants. Local anesthetics are used for local and regional anesthetic techniques. Mixed drugs (e.g., tramadol, tapentadol, serotonin/noradrenaline reuptake inhibitors) combine various mechanisms (Table 1). Acute and chronic pain are substantially different conditions. The treatment of...
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