ATP-Dependent K + Channels
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ATP-dependent potassium (KATP) channels are potassium selective ion channels present in a range of tissues. The defining property of KATP channels is their sensitivity to intracellular nucleotides. The channels are inhibited by ATP and activated by ADP and thus couple cellular metabolism to membrane excitability. The opening of KATP channels results in membrane hyperpolarization and reduces cellular excitability. The channel is a member of the inwardly rectifying family of potassium channels though the rectification it displays is relatively weak and thus KATP channels can significantly influence excitability whatever the resting membrane potential. The channels were first described in cardiac tissue (Noma 1983) but subsequently isolated in pancreatic β cells, neurons, and skeletal and smooth muscle (Tinker et al. 2018). In this essay we consider only those channels unequivocally constituted of Kir6.0 subunits; a large number of...
- Martin GM, Yoshioka C, Rex EA, Fay JF, Xie Q, Whorton MR, Chen JZ, Shyng SL (2017) Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating. Elife 6, available from: PM:28092267. https://doi.org/10.7554/eLife31054