Encyclopedia of Molecular Pharmacology

Living Edition
| Editors: Stefan Offermanns, Walter Rosenthal

A-Kinase Anchoring Proteins (AKAPs)

  • Ryan Walker-Gray
  • Enno KlussmannEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-030-21573-6_219-1



AKAPs are a diverse family of about 50 scaffolding proteins, which are defined by their ability to bind the regulatory subunits of cyclic AMP-dependent protein kinase (PKA; Fig. 1) [reviewed in (Welch et al. 2010)]. PKA is an abundant and ubiquitously expressed protein kinase. However, despite its ubiquity in signaling processes, there are only four isoforms of the PKA regulatory subunit with which to impart specificity in localization. Instead, the diversity of AKAPs that tether PKA along with other signaling proteins, including G protein-coupled receptors, adenylyl cyclases, kinases, phosphodiesterases, and phosphatases, among others, to create multivalent signaling complexes, dictates their localization and integrates cellular signaling processes at specific sites and times. The compartmentalization of signaling by AKAPs contributes to the specificity of cellular...
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Copyright information

© Springer-Verlag Berlin Heidelberg New York 2020

Authors and Affiliations

  1. 1.Max Delbrück Center for Molecular Medicine Berlin (MDC), Helmholtz AssociationBuch, BerlinGermany
  2. 2.DZHK (German Centre for Cardiovascular Research), partner site BerlinBerlinGermany