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Appetite control is a complex function of the brain that regulates feeding behavior. This function integrates cognitive and emotional factors with a complex array of peripheral signals originated from the gastrointestinal tract, adipose tissue.
Feeding behavior is subjected to both short-term regulation during a single meal and long-term regulation related to the maintenance of body weight and fat content. As a complex function of the brain, ingestive behavior is controlled by psychological and cognitive factors such as sociocultural context (e.g., eating habits), experience (sensory preferences), or emotional status (mood). Appetite control is regulated by the nutritional status, which can be sensed in the brain by glucose-sensing neuronal and non-neuronal cells to elicit an adaptive response. Appetite control also integrates information about the status of peripheral organs, particularly the...
- Zhao S, Zhu Y, Schultz RD, Li N, He Z, Zhang Z, Caron A, Zhu Q, Sun K, Xiong W, Deng H, Sun J, Deng Y, Kim M, Lee CE, Gordillo R, Liu T, Odle AK, Childs GV, Zhang N, Kusminski CM, Elmquist JK, Williams KW, An Z, Scherer PE (2019) Partial leptin reduction as an insulin sensitization and weight loss strategy. Cell Metab. https://doi.org/10.1016/j.cmet.2019.08.005