Encyclopedia of Molecular Pharmacology

Living Edition
| Editors: Stefan Offermanns, Walter Rosenthal

Appetite Control

  • André KleinriddersEmail author
  • Hans Georg Joost
Living reference work entry
DOI: https://doi.org/10.1007/978-3-030-21573-6_21-1



Appetite control is a complex function of the brain that regulates feeding behavior. This function integrates cognitive and emotional factors with a complex array of peripheral signals originated from the gastrointestinal tract, adipose tissue.

Basic Mechanisms

Feeding behavior is subjected to both short-term regulation during a single meal and long-term regulation related to the maintenance of body weight and fat content. As a complex function of the brain, ingestive behavior is controlled by psychological and cognitive factors such as sociocultural context (e.g., eating habits), experience (sensory preferences), or emotional status (mood). Appetite control is regulated by the nutritional status, which can be sensed in the brain by glucose-sensing neuronal and non-neuronal cells to elicit an adaptive response. Appetite control also integrates information about the status of peripheral organs, particularly the...

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Copyright information

© Springer-Verlag Berlin Heidelberg New York 2020

Authors and Affiliations

  1. 1.Junior Research Group Central Regulation of MetabolismGerman Institute of Human NutritionPotsdam-RehbrueckeGermany
  2. 2.German Center for Diabetes Research (DZD)München-NeuherbergGermany
  3. 3.Department of PharmacologyGerman Institute of Human NutritionPotsdam-RehbrueckeGermany