Encyclopedia of Molecular Pharmacology

Living Edition
| Editors: Stefan Offermanns, Walter Rosenthal

Atherosclerosis

  • Lokesh Kumar BhattEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-030-21573-6_206-1
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Synonyms

Arteriosclerosis (see Definition)

Definition

Atherosclerosis is an arterial disorder that comes from Greek words athera which means porridge and sclereni which means hardening of arteries. It is an inflammatory disorder, in which the lipid plaques along with inflammatory responses accumulate inside the arteries resulting in hardening and narrowing of the arteries and therefore restricting blood flow. Plaques are waxy substances that consist of lipids and oxidized lipids along with many inflammasomes. Plaques are complex, heterogenous composition which include fibrous caps, necrotic cells, and inflammatory responses (Barrett et al. 2019). Blockade of coronary artery (that supplies blood to the heart) with plaques hampers the blood flow to the heart, and the cardiac cells become deprived of oxygen. Symptoms of atherosclerosis in coronary artery include angina, vomiting, coughing, and anxiety, which eventually leads to myocardial ischemia. Plaques causing atherosclerosis of...

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg New York 2020

Authors and Affiliations

  1. 1.Department of PharmacologySVKM’s Dr. Bhanuben Nanavati College of PharmacyVile Parle (W)India