Encyclopedia of Molecular Pharmacology

Living Edition
| Editors: Stefan Offermanns, Walter Rosenthal

Antitussive Drugs

  • Clive P. PageEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-030-21573-6_185-1
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Definitions

Cough is an essential protective reflex response to irritating stimuli in the respiratory tract. It involves the sudden, usually involuntary, expulsion of air from the lungs. Cough can prevent foreign bodies from entering the lungs or aid the removal of mucus and irritants from the lungs. Cough is a common symptom in upper respiratory tract infections and more chronically in asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and lung cancer or may also indicate some other underlying disorders such as gastroesophageal reflux disease. It is also frequently caused by smoking. Conversely, in certain conditions such as Parkinson’s disease, stroke, and motor neuron disease, cough may be severely affected, and the patient loses this protective function. Cough is useful if it is aiding the expulsion of foreign substances, but chronic cough is an unpleasant, difficult symptom for patients to live with and maybe debilitating.

Basic Mechanisms

Ph...

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References

  1. Birring SS, Wijsenbeek MS, Agrawal S, van den Berg JWK, Stone H, Maher TM, Tutuncu A, Morice AH (2017) A novel formulation of inhaled sodium cromoglicate (PA1010) in idiopathic pulmonary fibrosis and chronic cough: a randomized, double-blind, proof-of-concept, phase 2 trial. Lancet Respir Med 5(10):806–815CrossRefGoogle Scholar
  2. Chung KF (2007) Effective antitussives for the cough patient: an unmet need. Pulm Pharmacol Ther 20:438–445CrossRefGoogle Scholar
  3. Dicpinigaitis PV (2006) Current and future peripherally-acting antitussives. Respir Physiol Neurobiol 152:356–362CrossRefGoogle Scholar
  4. Dicpinigaitis PV, Morice AH, Birring SS, McGarvey L, Smith JA, Canning BJ, Page CP (2014) Antitussive drugs – past, present, and future. Pharmacol Rev 66:468–512CrossRefGoogle Scholar
  5. Reynolds SM, Mackenzie AJ, Spina D et al (2004) The pharmacology of cough. Trends Pharmacol Sci 25:569–576CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg New York 2020

Authors and Affiliations

  1. 1.Sackler Institute of Pulmonary PharmacologyKing’s College LondonLondonUK