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Antiarrhythmic drugs (AADs) are a group of pharmaceuticals used to treat or prevent heart rhythm disorders (cardiac arrhythmias) by altering the electrophysiological properties of the heart, typically through direct interaction with ion channels, receptors, or pumps/exchangers (Dan et al. 2018).
During a normal heartbeat, electrical impulses generated in the sinoatrial node conduct across the atria to the atrioventricular node. After a brief delay, the electrical impulse rapidly conducts along the His-Purkinje conduction system, resulting in synchronous activation of both ventricles that is necessary for optimal pump function of the heart. During cardiac arrhythmias, electrical impulse formation and/or conduction is disturbed, leading to excessively fast, slow, or irregular electrical activity of one or more parts of the heart. Although cardiac arrhythmias can be completely asymptomatic, they often lead...
- Dan GA, Martinez-Rubio A, Agewall S, Boriani G, Borggrefe M, Gaita F, van Gelder I, Gorenek B, Kaski JC, Kjeldsen K, Lip GYH, Merkely B, Okumura K, Piccini JP, Potpara T, Poulsen BK, Saba M, Savelieva I, Tamargo JL, Wolpert C, Group ESCSD (2018) Antiarrhythmic drugs-clinical use and clinical decision making: a consensus document from the European Heart Rhythm Association (EHRA) and European Society of Cardiology (ESC) Working Group on Cardiovascular Pharmacology, endorsed by the Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS) and International Society of Cardiovascular Pharmacotherapy (ISCP). Europace 20(5):731–732an. https://doi.org/10.1093/europace/eux373CrossRefPubMedGoogle Scholar