Acid-Sensing Ion Channels
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Acid-sensing ion channels (ASICs) are non-voltage-gated sodium channels transiently activated by extracellular protons, selective for sodium, and belong to the epithelial sodium channel (ENaC)/degenerin (DEG) family of ion channels. The members of this ion channel superfamily share a similar topology with short intracellular amino and carboxy termini and two membrane-spanning domains connected by a large extracellular domain. The ASIC ion channel group consists of four genes encoding at least six ASIC subunits including 1a, 1b, 2a, 2b, 3, and 4.
Channel family, structural organization and function
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