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Tissue-Engineered Teeth

  • Living reference work entry
  • First Online:
Organ Tissue Engineering

Part of the book series: Reference Series in Biomedical Engineering ((TIENRE))

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Abstract

Clinical practice in the field of dentistry has remained largely unchanged for over a century. Recently, significant advances in the fields of tissue engineering and regenerative medicine (TERM) have provided new opportunities for dental therapies to advance in ways that will provide patients with more effective therapies to regenerate living dental tissue, while at the same time preserving natural dental tissues as much as possible. Since regenerative dental therapies are based on knowledge and understanding of natural tooth development, here we first describe early tooth development, including morphogenesis of tooth crown and root structures, and review new, relevant findings in tooth development biology. With respect to regenerative approaches for dental tissue repair, we next describe the three components recognized as doctrine in tissue engineering strategies – dental stem cells, scaffolds, and growth factors/signaling molecules/cytokines – and recent findings in each. We next review the use of dental stem cells for applications in tooth regeneration, including highlights on the use of innovative and promising scaffold materials and growth factors. We discuss the significant breakthrough and discovery in 2006 of induced pluripotent stem cells (iPSCs), and how this stem cell technology demonstrated the possibility of using a patient’s own reprogrammed cells to regenerate new tissues and organs. We next describe promising partial tooth regeneration strategies, including regeneration of the dentin-pulp complex, the periodontium, and tooth root regeneration. Finally, we describe exciting progress in whole tooth regeneration strategies, focusing on three-dimensional (3D) tissue engineering strategies.

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  1. Tufts University, Boston, MA, USA

    Zihan Li, Weibo Zhang & Pamela C. Yelick

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  1. Zihan Li
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  2. Weibo Zhang
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  3. Pamela C. Yelick
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Correspondence to Pamela C. Yelick .

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  1. Klinik für Urologie, NORD1 B200, Universitäts Spital, Zürich, Zürich, Switzerland

    Daniel Eberli

  2. Institute for Regenerative Medicine, Wake Forest University, Winston Salem, NC, USA

    Sang Jin Lee

  3. Inst of Tendon and Bone Regeneration, Paracelsus Medical University, Salzburg, Austria

    Andreas Traweger

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Li, Z., Zhang, W., Yelick, P.C. (2020). Tissue-Engineered Teeth. In: Eberli, D., Lee, S.J., Traweger, A. (eds) Organ Tissue Engineering. Reference Series in Biomedical Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-030-18512-1_10-1

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