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Allergy and Asthma pp 553–591Cite as

IgE Food Allergy

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Abstract

Food allergy has become a significant public health burden over the past decades with an ever increasing prevalence. Many different pathophysiologic mechanisms have been investigated and discussed. The current consensus on development of food allergies is the alteration of clinical and immunologic tolerance to foods. Pre- and postnatal exposures and other factors both in the patient and also the environment seem to be the main drivers in this altered immune state resulting in sensitization to food proteins.

Food allergies can present as many different entities. Pure IgE-mediated allergies are IgE-mediated food allergies or pollen-food cross-reactivities, while atopic dermatitis and eosinophilic esophagitis represent a mixed IgE-/cell-mediated sensitivity to food allergens.

Symptoms of adverse reactions to food allergens manifest in most organ systems, including the lungs, gastrointestinal tract, cardiovascular system, and the skin. Often more than one organ system is affected with anaphylaxis being the most severe and potentially resulting in death.

Clinical history, specific serum IgE testing and skin prick testing are the mainstay in diagnosis of food allergies. Novel diagnostic tools utilizing advances and availability of recombinant allergens and cellular and genetic testing are being investigated.

While novel treatment approaches that are focusing on achievement of tolerance or sustained unresponsiveness are being studied on the cellular level and in clinical trials, the mainstay of management remains strict avoidance of the food allergen.

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Authors and Affiliations

  1. Department of Pediatrics, Penn State Children’s Hospital, Hershey, PA, USA

    Sebastian Sylvestre

  2. Department of Pediatrics, Division of Pediatric Allergy/Immunology, Penn State Children’s Hospital, Hershey, PA, USA

    Doerthe Adriana Andreae

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  1. Sebastian Sylvestre
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Correspondence to Doerthe Adriana Andreae .

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  1. Division of Allergy & Immunology, University of South Florida, Tampa, FL, USA

    Dennis K. Ledford

  2. Milton S Hershey Med Ctr, Penn State University, Hershey, PA, USA

    Timothy Craig

  3. Penn State University, Hershey, PA, USA

    Tim Craig

  4. Department of Medicine, University of California, San Francisco, CA, USA

    Massoud Mahmoudi

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Sylvestre, S., Andreae, D.A. (2019). IgE Food Allergy. In: Allergy and Asthma. Springer, Cham. https://doi.org/10.1007/978-3-030-05147-1_26

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