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Acral Lentiginous Melanoma

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Cutaneous Melanoma

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Abstract

Acral lentiginous melanoma (ALM), described by Reed more than 30 years ago, has many unique characteristics. However, ALM is still a mysterious form of skin cancer. Of the four major subtypes of cutaneous melanoma (CM) worldwide, ALM is the rarest. Although ALM is the most common subtype of CM among Asians, Middle Easterners, and Africans, the absolute number of ALM cases is small. This is because CM is a rather rare skin cancer in Asia, Middle East, and Africa, compared to those in Western countries. ALM occurs on the palms, soles, and nails as unexposed lesions. The pathogeneses of ALM remain unknown. Furthermore, ALM has a more advanced status at diagnosis, and the prognosis of ALM is the worst among all types of CM. Several reasons for the poor prognosis are proposed from various perspectives; however, they have not been ascertained. Therefore, there is need for further studies to understand the nature of ALM, establish its original diagnosis, and identify treatment modalities for ALM in the future.

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Authors and Affiliations

  1. Department of Skin Oncology/Dermatology, Saitama Medical University International Medical Center, Saitama, Japan

    Yukiko Teramoto

  2. Melanoma Clinic, Surgical Oncology, Instituto Nacional de Cancerología, México City, Mexico

    Hector Martinez-Said

  3. Department of Renal Cancer and Melanoma, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Cancer Hospital and Institute, Beijing, China

    Jun Guo

  4. Centre for Dermatooncology, Department of Dermatology, Eberhard Karls University, Tuebingen, Germany

    Claus Garbe

Authors
  1. Yukiko Teramoto
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  2. Hector Martinez-Said
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  3. Jun Guo
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  4. Claus Garbe
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Corresponding author

Correspondence to Claus Garbe .

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Editors and Affiliations

  1. Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Charles M. Balch

  2. Department of Oncology, Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, DC, USA

    Michael B. Atkins

  3. Centre for Dermatooncology, Department of Dermatology, Eberhard Karls University, Tuebingen, Germany

    Claus Garbe

  4. Departments of Surgical Oncology and Cancer Biology, Melanoma and Skin Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Jeffrey E. Gershenwald

  5. Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Allan C. Halpern

  6. Departments of Medicine, Dermatology, and Translational Science, University of Pittsburgh and UPMC Hillman Cancer Center, Pittsburgh, PA, USA

    John M. Kirkwood

  7. Divisions of Cancer Medicine and Research, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia

    Grant A. McArthur

  8. Melanoma Institute Australia, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia

    John F. Thompson

  9. Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Arthur J. Sober

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Teramoto, Y., Martinez-Said, H., Guo, J., Garbe, C. (2020). Acral Lentiginous Melanoma. In: Balch, C., et al. Cutaneous Melanoma. Springer, Cham. https://doi.org/10.1007/978-3-030-05070-2_67

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  • DOI: https://doi.org/10.1007/978-3-030-05070-2_67

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