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Biopsy of the Sentinel Lymph Node

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Cutaneous Melanoma

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Abstract

Lymphatic mapping and sentinel lymph node biopsy are standard components of the care of newly diagnosed patients with clinically localized intermediate- and high-risk melanoma. The procedures are the culmination of a long evolution of the management of regional lymph nodes in newly diagnosed patients. Sentinel lymph node biopsy is the most accurate staging method currently available and can be performed with limited morbidity. This staging information is of critical importance in an era of rapidly changing and improving systemic therapy. Alone or with completion lymph node dissection, sentinel lymph node biopsy enhances regional disease control and appears to improve melanoma-specific survival for some patients. The sentinel lymph node also appears to be a potentially rich subject for investigations of melanoma-host interactions.

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References

  • Abrahamsen HN, Hamilton-Dutoit SJ, Larsen J, Steiniche T (2004) Sentinel lymph nodes in malignant melanoma: extended histopathologic evaluation improves diagnostic precision. Cancer 100(8):1683–1691

    Article  PubMed  Google Scholar 

  • Alex JC, Krag DN (1993) Gamma-probe guided localization of lymph nodes. Surg Oncol 2(3):137–143

    Article  CAS  PubMed  Google Scholar 

  • Altstein LL, Li G, Elashoff RM (2011) A method to estimate treatment efficacy among latent subgroups of a randomized clinical trial. Stat Med 30(7):709–717

    Article  PubMed  Google Scholar 

  • Ariyan S, Ali-Salaam P, Cheng DW, Truini C (2007) Reliability of lymphatic mapping after wide local excision of cutaneous melanoma. Ann Surg Oncol 14(8):2377–2383

    Article  PubMed  Google Scholar 

  • Ariyan C, Brady MS, Gonen M, Busam K, Coit D (2009) Positive non-sentinel node status predicts mortality in patients with cutaneous melanoma. Ann Surg Oncol 16(1):186–190

    Article  PubMed  Google Scholar 

  • Balch CM, Murad TM, Soong S-J, Ingalls AL, Richards PC, Maddox WA (1979) Tumor thickness as a guide to surgical management of clinical stage I melanoma patients. Cancer 43(3):883-888

    Article  CAS  PubMed  Google Scholar 

  • Balch CM, Soong SJ (1983) Characteristics of melanoma that predict the risk of metastases. In: Costanzi JJ (ed) Malignant melanoma 1. Cancer treatment and research, vol 9. Springer, Boston, pp 123–125

    Google Scholar 

  • Balch C, Soong S, Ross M, Urist M, Karakousis C, Temple W, Mihm JMC, Barnhill R, Jewell W, Wanebo H, Harrison R (2000) Long-term results of a multi-institutional randomized trial comparing prognostic factors and surgical results for intermediate thickness melanomas (1.0–4.0 mm). Ann Surg Oncol 7(2):87–97

    Article  CAS  PubMed  Google Scholar 

  • Balch CM, Cascinelli N, Sim FH (2003) Elective lymph node dissection: results of prospective randomized surgical trials. In: Balch CM, Houghton AN, Sober AJ, Soong SJ (eds) Cutaneous melanoma, vol 4th. Quality Medical Publishing, Saint Louis, pp 379–395

    Google Scholar 

  • Bamboat ZM, Konstantinidis IT, Kuk D, Ariyan CE, Brady MS, Coit DG (2014) Observation after a positive sentinel lymph node biopsy in patients with melanoma. Ann Surg Oncol 21(9):3117–3123

    Article  PubMed  Google Scholar 

  • Barbour AH, Coventry BJ (2003) Dendritic cell density and activation status of tumour-infiltrating lymphocytes in metastatic human melanoma: possible implications for sentinel node metastases. Melanoma Res 13(3):263–269

    Article  PubMed  Google Scholar 

  • Beasley G, Tyler D (2015) In-transit melanoma metastases: incidence, prognosis, and the role of lymphadenectomy. Ann Surg Oncol 22(2):358–360

    Article  PubMed  Google Scholar 

  • Bichakjian CK, Halpern AC, Johnson TM, Foote Hood A, Grichnik JM, Swetter SM, Tsao H, Barbosa VH, Chuang TY, Duvic M, Ho VC, Sober AJ, Beutner KR, Bhushan R, Smith Begolka W (2011) Guidelines of care for the management of primary cutaneous melanoma. American Academy of Dermatology. J Am Acad Dermatol 65(5):1032–1047

    Article  PubMed  Google Scholar 

  • Bilimoria KY, Balch CM, Bentrem DJ, Talamonti MS, Ko CY, Lange JR, Winchester DP, Wayne JD (2008) Complete lymph node dissection for sentinel node-positive melanoma: assessment of practice patterns in the United States. Ann Surg Oncol 15(6):1566–1576

    Article  PubMed  Google Scholar 

  • Botella-Estrada R, Dasi F, Ramos D, Nagore E, Herrero MJ, Gimenez J, Fuster C, Sanmartin O, Guillen C, Alino S (2005) Cytokine expression and dendritic cell density in melanoma sentinel nodes. Melanoma Res 15(2):99–106

    Article  CAS  PubMed  Google Scholar 

  • Braithwaite L (1923) The flow of lymph from the ileocaecal angle, and its possible bearing on the cause of duodenal and gastric ulcer. Br J Surg 11:7–26

    Article  Google Scholar 

  • Cabanas R (1977) An approach for the treatment of penile carcinoma. Cancer 39(2):456–466

    Article  CAS  PubMed  Google Scholar 

  • Cadili A, Dabbs K, Scolyer RA, Brown PT, Thompson JF (2010) Re-evaluation of a scoring system to predict nonsentinel-node metastasis and prognosis in melanoma patients. J Am Coll Surg 211(4):522–525

    Article  PubMed  Google Scholar 

  • Cammilleri S, Jacob T, Rojat-Habib MC, Hesse S, Berthet B, Giorgi R, Bonerandi JJ, Mundler O (2004) High negative predictive value of slow lymphatic drainage on metastatic node spread detection in malignant limb and trunk cutaneous melanoma. Bull Cancer 91(7–8):E225–E228

    CAS  PubMed  Google Scholar 

  • Caraco C, Marone U, Di Monta G, Aloj L, Caraco C, Anniciello A, Lastoria S, Botti G, Mozzillo N (2014) Surgical management of sentinel lymph node biopsy outside major nodal basin in patients with cutaneous melanoma. Ann Surg Oncol 21(1):300–305

    Article  PubMed  Google Scholar 

  • Carson KF, Wen DR, Li PX, Lana AM, Bailly C, Morton DL, Cochran AJ (1996) Nodal nevi and cutaneous melanomas. Am J Surg Pathol 20(7):834–840

    Article  CAS  PubMed  Google Scholar 

  • Chai CY, Zager JS, Szabunio MM, Marzban SS, Chau A, Rossi RM, Sondak VK (2012) Preoperative ultrasound is not useful for identifying nodal metastasis in melanoma patients undergoing sentinel node biopsy: preoperative ultrasound in clinically node-negative melanoma. Ann Surg Oncol 19(4):1100–1106

    Article  PubMed  Google Scholar 

  • Chakera AH, Hesse B, Burak Z, Ballinger JR, Britten A, Caraco C, Cochran AJ, Cook MG, Drzewiecki KT, Even-Sapir E, Eggermont AM, Stopar TG, Ingvar C, Mihm MC Jr, McCarthy SW, Mozzillo N, Nieweg OE, Scolyer RA, Starz H, Thompson JF, Trifiro G, Viale G, Vidal-Sicart S, Uren R, Waddington W, Chiti A, Spatz A, Testori A (2009) EANM-EORTC general recommendations for sentinel node diagnostics in melanoma. Eur J Nucl Med Mol Imaging 36(10):1713–1742

    Article  CAS  PubMed  Google Scholar 

  • Chapman BC, Gleisner A, Kwak JJ, Hosokawa P, Paniccia A, Merkow JS, Koo PJ, Gajdos C, Pearlman NW, McCarter MD, Kounalakis N (2016) SPECT/CT improves detection of metastatic sentinel lymph nodes in patients with head and neck melanoma. Ann Surg Oncol 23(8):2652–2657

    Article  PubMed  Google Scholar 

  • Chen PL, Chen WS, Li J, Lind AC, Lu D (2013) Diagnostic utility of neural stem and progenitor cell markers nestin and SOX2 in distinguishing nodal melanocytic nevi from metastatic melanomas. Mod Pathol 26(1):44–53

    Article  CAS  PubMed  Google Scholar 

  • Cochran AJ, Pihl E, Wen DR, Hoon DS, Korn EL (1987) Zoned immune suppression of lymph nodes draining malignant melanoma: histologic and immunohistologic studies. J Natl Cancer Inst 78(3):399–405

    CAS  PubMed  Google Scholar 

  • Cochran AJ, Lana AM, Wen DR (1989a) Histomorphometry in the assessment of prognosis in stage II malignant melanoma. Am J Surg Pathol 13(7):600–604

    Article  CAS  PubMed  Google Scholar 

  • Cochran AJ, Wen DR, Farzad Z, Stene MA, McBride W, Lana AM, Hoon DS, Morton DL (1989b) Immunosuppression by melanoma cells as a factor in the generation of metastatic disease. Anticancer Res 9(4):859–864

    CAS  PubMed  Google Scholar 

  • Cochran AJ, Morton DL, Stern S, Lana AM, Essner R, Wen DR (2001) Sentinel lymph nodes show profound downregulation of antigen-presenting cells of the paracortex: implications for tumor biology and treatment. Mod Pathol 14(6):604–608

    Article  CAS  PubMed  Google Scholar 

  • Cochran AJ, Huang RR, Lee J, Itakura E, Leong SP, Essner R (2006) Tumour-induced immune modulation of sentinel lymph nodes. Nat Rev Immunol 6(9):659–670

    Article  CAS  PubMed  Google Scholar 

  • Cochran AJ, Ohsie SJ, Binder SW (2008) Pathobiology of the sentinel node. Curr Opin Oncol 20(2):190–195

    Article  PubMed  Google Scholar 

  • Coit DG, Thompson JA, Algazi A, Andtbacka R, Bichakjian CK, Carson WE 3rd, Daniels GA, DiMaio D, Ernstoff M, Fields RC, Fleming MD, Gonzalez R, Guild V, Halpern AC, Hodi FS Jr, Joseph RW, Lange JR, Martini MC, Materin MA, Olszanski AJ, Ross MI, Salama AK, Skitzki J, Sosman J, Swetter SM, Tanabe KK, Torres-Roca JF, Trisal V, Urist MM, McMillian N, Engh A (2016) Melanoma, version 2.2016, NCCN clinical practice guidelines in oncology. J Natl Compr Cancer Netw 14(4):450–473

    Article  Google Scholar 

  • Dadras SS, Lange-Asschenfeldt B, Velasco P, Nguyen L, Vora A, Muzikansky A, Jahnke K, Hauschild A, Hirakawa S, Mihm MC, Detmar M (2005) Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes. Mod Pathol 18(9):1232–1242

    Article  PubMed  Google Scholar 

  • Dessureault S, Soong SJ, Ross MI, Thompson JF, Kirkwood JM, Gershenwald JE, Coit DG, McMasters KM, Balch CM, Reintgen D (2001) Improved staging of node-negative patients with intermediate to thick melanomas (>1mm) with the use of lymphatic mapping and sentinel lymph node biopsy. Ann Surg Oncol 8(10):766–770

    Article  CAS  PubMed  Google Scholar 

  • Dewar DJ, Newell B, Green MA, Topping AP, Powell BW, Cook MG (2004) The microanatomic location of metastatic melanoma in sentinel lymph nodes predicts nonsentinel lymph node involvement. J Clin Oncol 22(16):3345–3349

    Article  CAS  PubMed  Google Scholar 

  • Doepker MP, Yamamoto M, Applebaum MA, Patel NU, Jaime Montilla-Soler M, Sarnaik AA, Wayne Cruse C, Sondak VK, Zager JS (2017) Comparison of single-photon emission computed tomography-computed tomography (SPECT/CT) and conventional planar lymphoscintigraphy for sentinel node localization in patients with cutaneous malignancies. Ann Surg Oncol 24(2):355–361

    Article  PubMed  Google Scholar 

  • Egger ME, Xiao D, Hao H, Kimbrough CW, Pan J, Rai SN, Cambon AC, Waigel SJ, Zacharias W, McMasters KM (2018) Unique genes in tumor-positive sentinel lymph nodes associated with nonsentinel lymph node metastases in melanoma. Ann Surg Oncol 25(5):1296–1303

    Article  PubMed  Google Scholar 

  • Evans HL, Krag DN, Teates CD, Patterson JW, Meijer S, Harlow SP, Tanabe KK, Loggie BW, Whitworth PW, Kusminsky RE, Carp NZ, Gadd MA, Slingluff CL Jr (2003) Lymphoscintigraphy and sentinel node biopsy accurately stage melanoma in patients presenting after wide local excision. Ann Surg Oncol 10(4):416–425

    Article  PubMed  Google Scholar 

  • Faries MB, Bleicher RJ, Ye X, Essner R, Morton DL (2004) Lymphatic mapping and sentinel lymphadenectomy for primary and metastatic pulmonary malignant neoplasms. Arch Surg 139(8):870–876; discussion 876–877

    Article  PubMed  Google Scholar 

  • Faries MB, Thompson JF, Cochran A, Elashoff R, Glass EC, Mozzillo N, Nieweg OE, Roses DF, Hoekstra HJ, Karakousis CP, Reintgen DS, Coventry BJ, Wang HJ, Morton DL (2010) The impact on morbidity and length of stay of early versus delayed complete lymphadenectomy in melanoma: results of the multicenter selective lymphadenectomy trial (I). Ann Surg Oncol 17(12):3324–3329

    Article  PubMed  PubMed Central  Google Scholar 

  • Faries MB, Thompson JF, Cochran AJ, Andtbacka RH, Mozzillo N, Zager JS, Jahkola T, Bowles TL, Testori A, Beitsch PD, Hoekstra HJ, Moncrieff M, Ingvar C, Wouters M, Sabel MS, Levine EA, Agnese D, Henderson M, Dummer R, Rossi CR, Neves RI, Trocha SD, Wright F, Byrd DR, Matter M, Hsueh E, MacKenzie-Ross A, Johnson DB, Terheyden P, Berger AC, Huston TL, Wayne JD, Smithers BM, Neuman HB, Schneebaum S, Gershenwald JE, Ariyan CE, Desai DC, Jacobs L, McMasters KM, Gesierich A, Hersey P, Bines SD, Kane JM, Barth RJ, McKinnon G, Farma JM, Schultz E, Vidal-Sicart S, Hoefer RA, Lewis JM, Scheri R, Kelley MC, Nieweg OE, Noyes RD, Hoon DSB, Wang HJ, Elashoff DA, Elashoff RM (2017) Completion dissection or observation for sentinel-node metastasis in Melanoma. N Engl J Med 376(23):2211–2222

    Article  PubMed  PubMed Central  Google Scholar 

  • Gannon CJ, Rousseau DL Jr, Ross MI, Johnson MM, Lee JE, Mansfield PF, Cormier JN, Prieto VG, Gershenwald JE (2006) Accuracy of lymphatic mapping and sentinel lymph node biopsy after previous wide local excision in patients with primary melanoma. Cancer 107(11):2647–2652

    Article  PubMed  Google Scholar 

  • Gerami P, Cook RW, Russell MC, Wilkinson J, Amaria RN, Gonzalez R, Lyle S, Jackson GL, Greisinger AJ, Johnson CE, Oelschlager KM, Stone JF, Maetzold DJ, Ferris LK, Wayne JD, Cooper C, Obregon R, Delman KA, Lawson D (2015) Gene expression profiling for molecular staging of cutaneous melanoma in patients undergoing sentinel lymph node biopsy. J Am Acad Dermatol 72(5):780–785 e783

    Article  CAS  PubMed  Google Scholar 

  • Gershenwald JE, Andtbacka RHI, Prieto VG, Johnson MM, Hafeez Diwan A, Lee JE, Mansfield PF, Cormier JN, Schacherer CW, Ross MI (2008) Microscopic tumor burden in sentinel lymph nodes predicts synchronous non-sentinel lymph node involvement in patients with Melanoma. J Clin Oncol 26(16):4296–4303

    Article  PubMed  PubMed Central  Google Scholar 

  • Ghaferi AA, Wong SL, Johnson TM, Lowe L, Chang AE, Cimmino VM, Bradford CR, Rees RS, Sabel MS (2009) Prognostic significance of a positive nonsentinel lymph node in cutaneous melanoma. Ann Surg Oncol 16(11):2978–2984

    Article  PubMed  Google Scholar 

  • Gonzalez AB, Jakub JW, Harmsen WS, Suman VJ, Markovic SN (2016) Status of the Regional Nodal Basin remains highly prognostic in melanoma patients with in-transit disease. J Am Coll Surg 223(1):77–85 e71

    Article  PubMed  Google Scholar 

  • Gould EA, Winship T, Philbin PH, Kerr HH (1960) Observations on a “sentinel node” in cancer of the parotid. Cancer 13:77–78

    Article  CAS  PubMed  Google Scholar 

  • Grotz TE, Jakub JW, Mansfield AS, Goldenstein R, Enninga EA, Nevala WK, Leontovich AA, Markovic SN (2015) Evidence of Th2 polarization of the sentinel lymph node (SLN) in melanoma. Oncoimmunology 4(8):e1026504

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gyorki DE, Sanelli A, Herschtal A, Lazarakis S, McArthur GA, Speakman D, Spillane J, Henderson MA (2016) Sentinel lymph node biopsy in T4 Melanoma: an important risk-stratification tool. Ann Surg Oncol 23(2):579–584

    Article  PubMed  Google Scholar 

  • Han D, Zager JS, Shyr Y, Chen H, Berry LD, Iyengar S, Djulbegovic M, Weber JL, Marzban SS, Sondak VK, Messina JL, Vetto JT, White RL, Pockaj B, Mozzillo N, Charney KJ, Avisar E, Krouse R, Kashani-Sabet M, Leong SP (2013) Clinicopathologic predictors of sentinel lymph node metastasis in thin melanoma. J Clin Oncol 31(35):4387–4393

    Article  PubMed  Google Scholar 

  • Harrell MI, Iritani BM, Ruddell A (2007) Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis. Am J Pathol 170(2):774–786

    Article  PubMed  PubMed Central  Google Scholar 

  • Herbert G, Karakousis GC, Bartlett EK, Zaheer S, Graham D, Czerniecki BJ, Fraker DL, Ariyan C, Coit DG, Brady MS (2018) Transected thin melanoma: implications for sentinel lymph node staging. J Surg Oncol 117(4):567–571

    Article  PubMed  Google Scholar 

  • Holmes E, Moseley H, Morton D, Clark W, Robinson D, Urist M (1977) A rational approach to the surgical management of melanoma. Ann Surg 186(4):481–490

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hyngstrom JR, Chiang YJ, Cromwell KD, Ross MI, Xing Y, Mungovan KS, Lee JE, Gershenwald JE, Royal RE, Lucci A, Armer JM, Cormier JN (2013) Prospective assessment of lymphedema incidence and lymphedema-associated symptoms following lymph node surgery for melanoma. Melanoma Res 23(4):290–297

    PubMed  Google Scholar 

  • Jafari SMS, Jackle P, Michel A, Angermeier S, Hunger R, Shafighi M (2016) Prognostic value of sentinel lymph node biopsy in melanomas of different Breslow’s thickness. Swiss Med Wkly 146:1–8

    Google Scholar 

  • Karakousis G, Gimotty PA, Bartlett EK, Sim MS, Neuwirth MG, Fraker D, Czerniecki BJ, Faries MB (2017) Thin melanoma with nodal involvement: analysis of demographic, pathologic, and treatment factors with regard to prognosis. Ann Surg Oncol 24(4):952–959

    Article  PubMed  Google Scholar 

  • Karim RZ, Scolyer RA, Li W, Yee VS, McKinnon JG, Li LX, Uren RF, Lam S, Beavis A, Dawson M, Doble P, Hoon DS, Thompson JF (2008) False negative sentinel lymph node biopsies in melanoma may result from deficiencies in nuclear medicine, surgery, or pathology. Ann Surg 247(6):1003–1010

    Article  PubMed  Google Scholar 

  • Kelemen PR, Essner R, Foshag LJ, Morton DL (1999) Lymphatic mapping and sentinel lymphadenectomy after wide local excision of primary melanoma. J Am Coll Surg 189(3):247–252

    Article  CAS  PubMed  Google Scholar 

  • Kidner TB, Yoon JL, Faries MB, Morton DL (2012) Epitrochlear sentinel lymph nodes in melanoma: interval or independent? Am Surg 78(6):702–705

    PubMed  PubMed Central  Google Scholar 

  • Koshenkov VP, Shulkin D, Bustami R, Chevinsky AH, Whitman ED (2012) Role of sentinel lymphadenectomy in thin cutaneous melanomas with positive deep margins on initial biopsy. J Surg Oncol 106(4):363–368

    Article  PubMed  Google Scholar 

  • Lee DY, Huynh KT, Teng A, Lau BJ, Vitug S, Lee JH, Stern SL, Foshag LJ, Faries MB (2016) Predictors and survival impact of false-negative sentinel nodes in melanoma. Ann Surg Oncol 23(3):1012–1018

    Article  PubMed  Google Scholar 

  • Leiter U, Stadler R, Mauch C, Hohenberger W, Brockmeyer N, Berking C, Sunderkotter C, Kaatz M, Schulte KW, Lehmann P, Vogt T, Ulrich J, Herbst R, Gehring W, Simon JC, Keim U, Martus P, Garbe C, G. German Dermatologic Cooperative Oncology (2016) Complete lymph node dissection versus no dissection in patients with sentinel lymph node biopsy positive melanoma (DeCOG-SLT): a multicentre, randomised, phase 3 trial. Lancet Oncol 17(6):757–767

    Article  PubMed  Google Scholar 

  • Lens MB, Dawes M, Goodacre T, Newton-Bishop JA (2002) Elective lymph node dissection in patients with melanoma: systematic review and meta-analysis of randomized controlled trials. Arch Surg 137(4):458–461

    Article  PubMed  Google Scholar 

  • Leong S, Enders-Zohr P, Zhou Y, Stuntebeck S, Habib F, Allen R Jr, Sagebeil R, Glassberg A, Lowenberg D, Hayes F (1999) Recombinant human granulocyte macrophage-colony stimulating factor (rhGM-CSF) and autologous melanoma vaccine mediate tumor regression in patients with metastatic melanoma. J Immunother 22:166–174

    Article  CAS  PubMed  Google Scholar 

  • Leung AM, Morton DL, Ozao-Choy J, Hari DM, Shin-Sim M, Difronzo AL, Faries MB (2013) Staging of regional lymph nodes in melanoma: a case for including nonsentinel lymph node positivity in the American Joint Committee on Cancer staging system. JAMA Surg 148(9):879–884

    Article  PubMed  Google Scholar 

  • Lo SN, Scolyer RA, Thompson JF (2018) Long-term survival of patients with thin (T1) cutaneous melanomas: a Breslow thickness cut point of 0.8 mm separates higher-risk and lower-risk tumors. Ann Surg Oncol 25(4):894–902

    Article  PubMed  Google Scholar 

  • Long X, Huang JZ, Ho YS (2014) A historical review of classic articles in surgery field. Am J Surg 208(5):841–849

    Article  PubMed  Google Scholar 

  • Lowe M, Hill N, Page A, Chen S, Delman KA (2011) The impact of shave biopsy on the management of patients with thin melanomas. Am Surg 77(8):1050–1053

    PubMed  Google Scholar 

  • Maus RLG, Jakub JW, Nevala WK, Christensen TA, Noble-Orcutt K, Sachs Z, Hieken TJ, Markovic SN (2017) Human melanoma-derived extracellular vesicles regulate dendritic cell maturation. Front Immunol 8:358

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Maza S, Valencia R, Geworski L, Sandrock D, Zander A, Audring H, Drager E, Winter H, Sterry W, Munz DL (2003) Influence of fast lymphatic drainage on metastatic spread in cutaneous malignant melanoma: a prospective feasibility study. Eur J Nucl Med Mol Imaging 30(4):538–544

    Article  PubMed  Google Scholar 

  • McMasters K, Reintgen D, Ross M, Wong S, Gershenwald J, Krag D, Noyes D, Viar V, Cerrito P, Edwards M (2001) Sentinel lymph node biopsy for melanoma: how many radioactive nodes should be removed? Ann Surg Oncol 8(3):192–197

    Article  CAS  PubMed  Google Scholar 

  • McMasters KM, Noyes RD, Reintgen DS, Goydos JS, Beitsch PD, Davidson BS, Sussman JJ, Gershenwald JE, Ross MI, Sunbelt Melanoma T (2004) Lessons learned from the sunbelt melanoma trial. J Surg Oncol 86(4):212–223

    Article  PubMed  Google Scholar 

  • Morton D, Wen D, Wong J, Economou J, Cagle L, Storm F, Foshag L, Cochran A (1992) Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg 127(4):392–399

    Article  CAS  PubMed  Google Scholar 

  • Morton D, Hoon D, Cochran A, Turner R, Essner R, Takeuchi H, Wanek L, Glass E, Foshag L, Hsueh E, Bilchik A, Elashoff D, Elashoff R (2003) Lymphatic mapping and sentinel lymphadenectomy for early-stage melanoma: therapeutic utility and implications of nodal microanatomy and molecular staging for improving the accuracy of detection of nodal micrometastases. Ann Surg 238(4):538–549

    PubMed  PubMed Central  Google Scholar 

  • Morton D, Cochran A, Thompson J, Essner R, Glass E, Mozzillo N, Nieweg O, Roses D, Hoekstra H, Karakousis C, Reintgen D, Coventry B, Wang H (2005) Sentinel node biopsy for early-stage melanoma: accuracy and morbidity in MSLT-1, an interanational multicenter trial. Ann Surg 242(3):302–311

    PubMed  PubMed Central  Google Scholar 

  • Morton DL, Thompson JF, Cochran AJ, Mozzillo N, Nieweg OE, Roses DF, Hoekstra HJ, Karakousis CP, Puleo CA, Coventry BJ, Kashani-Sabet M, Smithers BM, Paul E, Kraybill WG, McKinnon JG, Wang HJ, Elashoff R, Faries MB, Group M (2014) Final trial report of sentinel-node biopsy versus nodal observation in melanoma. N Engl J Med 370(7):599–609

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mozzillo N, Pennacchioli E, Gandini S, Caraco C, Crispo A, Botti G, Lastoria S, Barberis M, Verrecchia F, Testori A (2013) Sentinel node biopsy in thin and thick melanoma. Ann Surg Oncol 20(8):2780–2786

    Article  PubMed  Google Scholar 

  • Neves RI, Reynolds BQ, Hazard SW, Saunders B, Mackay DR (2011) Increased post-operative complications with methylene blue versus lymphazurin in sentinel lymph node biopsies for skin cancers. J Surg Oncol 103(5):421–425

    Article  PubMed  Google Scholar 

  • Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW (2008) Immunohistochemical characteristics of melanoma. J Cutan Pathol 35(5):433–444

    Article  PubMed  Google Scholar 

  • Pastushenko I, Van den Eynden GG, Vicente-Arregui S, Prieto-Torres L, Alvarez-Alegret R, Querol I, Dirix LY, Carapeto FJ, Vermeulen PB, Van Laere SJ (2016) Increased angiogenesis and lymphangiogenesis in metastatic sentinel lymph nodes is associated with nonsentinel lymph node involvement and distant metastasis in patients with melanoma. Am J Dermatopathol 38(5):338–346

    Article  PubMed  Google Scholar 

  • Ranieri JM, Wagner JD, Wenck S, Johnson CS, Coleman JJ 3rd (2006) The prognostic importance of sentinel lymph node biopsy in thin melanoma. Ann Surg Oncol 13(7):927–932

    Article  PubMed  Google Scholar 

  • Read RL, Haydu L, Saw RP, Quinn MJ, Shannon K, Spillane AJ, Stretch JR, Scolyer RA, Thompson JF (2015) In-transit melanoma metastases: incidence, prognosis, and the role of lymphadenectomy. Ann Surg Oncol 22(2):475–481

    Article  PubMed  Google Scholar 

  • Reintgen M, Murray L, Akman K, Giuliano R, Lozicki A, Shivers S, Reintgen D (2013) Evidence for a better nodal staging system for melanoma: the clinical relevance of metastatic disease confined to the sentinel lymph nodes. Ann Surg Oncol 20(2):668–674

    Article  PubMed  Google Scholar 

  • Schuitevoerder D, Grinlington L, Stevens J, Nance R, Fortino J, Vetto JT (2017) Nonvisualized sentinel lymph nodes on lymphoscintigraphy in melanoma: predictive factors and surgical outcomes. Nucl Med Commun 38(5):383–387

    Article  PubMed  Google Scholar 

  • Snow HM (1892) Melanotic cancerous disease. Lancet 140(3607):869–922

    Article  Google Scholar 

  • Sondak VK, Messina JL, Zager JS (2017) Selecting patients with thin melanoma for sentinel lymph node biopsy-this time it’s personal. JAMA Dermatol 153(9):857–858

    Article  PubMed  Google Scholar 

  • Spanknebel K, Coit DG, Bieligk SC, Gonen M, Rosai J, Klimstra DS (2005) Characterization of micrometastatic disease in melanoma sentinel lymph nodes by enhanced pathology: recommendations for standardizing pathologic analysis. Am J Surg Pathol 29(3):305–317

    Article  PubMed  Google Scholar 

  • Speeckaert R, Vermaelen K, van Geel N, Autier P, Lambert J, Haspeslagh M, van Gele M, Thielemans K, Neyns B, Roche N, Verbeke N, Deron P, Speeckaert M, Brochez L (2012) Indoleamine 2,3-dioxygenase, a new prognostic marker in sentinel lymph nodes of melanoma patients. Eur J Cancer 48(13):2004–2011

    Article  CAS  PubMed  Google Scholar 

  • Starz H, Balda BR, Kramer KU, Buchels H, Wang H (2001) A micromorphometry-based concept for routine classification of sentinel lymph node metastases and its clinical relevance for patients with melanoma. Cancer 91(11):2110–2121

    Article  CAS  PubMed  Google Scholar 

  • Steen ST, Kargozaran H, Moran CJ, Shin-Sim M, Morton DL, Faries MB (2011) Management of popliteal sentinel nodes in melanoma. J Am Coll Surg 213(1):180–186; discussion 186–187

    Article  PubMed  PubMed Central  Google Scholar 

  • Stoffels I, Boy C, Poppel T, Kuhn J, Klotgen K, Dissemond J, Schadendorf D, Klode J (2012) Association between sentinel lymph node excision with or without preoperative SPECT/CT and metastatic node detection and disease-free survival in melanoma. JAMA 308(10):1007–1014

    Article  CAS  PubMed  Google Scholar 

  • Testori A, Lazzaro G, Baldini F, Tosti G, Mosconi M, Lovati E, Bossi C, Sanvito S, Stanganelli I, Mazzarol G, De Salvo GL, Trifiro G, Biffi R, Bellomi M (2005) The role of ultrasound of sentinel nodes in the pre- and post-operative evaluation of stage I melanoma patients. Melanoma Res 15(3):191–198

    Article  PubMed  Google Scholar 

  • Thompson JF, Haydu LE, Sanki A, Uren RF (2011) Ultrasound assessment of lymph nodes in the management of early-stage melanoma. J Surg Oncol 104(4):354–360

    Article  PubMed  Google Scholar 

  • van den Hout M, Koster BD, Sluijter BJR, Molenkamp BG, van de Ven R, van den Eertwegh AJM, Scheper RJ, van Leeuwen PAM, van den Tol MP, de Gruijl TD (2017) Melanoma sequentially suppresses different DC subsets in the sentinel lymph node, affecting disease spread and recurrence. Cancer Immunol Res 5(11):969–977

    Article  PubMed  CAS  Google Scholar 

  • Veronesi U, Adamus J, Bandiera DC, Brennhovd IO, Caceres E, Cascinelli N, Claudio F, Ikonopisov RL, Javorskj VV, Kirov S, Kulakowski A, Lacoub J, Lejeune F, Mechl Z, Morabito A, Rode I, Sergeev S, van Slooten E, Szcygiel K, Trapeznikov NN (1977) Inefficacy of immediate node dissection in stage 1 melanoma of the limbs. N Engl J Med 297(12):627–630

    Article  CAS  PubMed  Google Scholar 

  • Veronesi U, Adamus J, Bandiera DC, Brennhovd O, Caceres E, Cascinelli N, Claudio F, Ikonopisov RL, Javorski VV, Kirov S, Kulakowski A, Lacour J, Lejeune F, Mechl Z, Morabito A, Rode I, Sergeev S, van Slooten E, Szczygiel K, Trapeznikov NN, Wagner RI (1982) Delayed regional lymph node dissection in stage I melanoma of the skin of the lower extremities. Cancer 49(11):2420–2430

    Article  CAS  PubMed  Google Scholar 

  • Verwer N, Scolyer RA, Uren RF, Winstanley J, Brown PT, de Wilt JH, Thompson JF (2011) Treatment and prognostic significance of positive interval sentinel nodes in patients with primary cutaneous melanoma. Ann Surg Oncol 18(12):3292–3299

    Article  PubMed  Google Scholar 

  • Virchow RLK (1860) Cellular pathology as based upon physiological and pathological histology. John Churchill, London

    Google Scholar 

  • Voss RK, Cromwell KD, Chiang YJ, Armer JM, Ross MI, Lee JE, Gershenwald JE, Stewart BR, Shaitelman SF, Cormier JN (2015) The long-term risk of upper-extremity lymphedema is two-fold higher in breast cancer patients than in melanoma patients. J Surg Oncol 112(8):834–840

    Article  PubMed  PubMed Central  Google Scholar 

  • Wen DR, Huang RR, Binder S, Morton DL, Cochran AJ (2004) Evaluation of melanoma in non-sentinel nodes: how much is enough? Mod Pathol 17(Suppl 1):100

    Google Scholar 

  • Wevers KP, Murali R, Bastiaannet E, Scolyer RA, Suurmeijer AJ, Thompson JF, Hoekstra HJ (2013) Assessment of a new scoring system for predicting non-sentinel node positivity in sentinel node-positive melanoma patients. Eur J Surg Oncol 39(2):179–184

    Article  CAS  PubMed  Google Scholar 

  • Wong J, Cagle L, Morton D (1991) Lymphatic drainage of skin to a sentinel lymph node in a feline model. Ann Surg 214(5):637–641

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wong SL, Brady MS, Busam KJ, Coit DG (2006) Results of sentinel lymph node biopsy in patients with thin melanoma. Ann Surg Oncol 13(3):302–309

    Article  PubMed  Google Scholar 

  • Wong SL, Faries MB, Kennedy EB, Agarwala SS, Akhurst TJ, Ariyan C, Balch CM, Berman BS, Cochran A, Delman KA, Gorman M, Kirkwood JM, Moncrieff MD, Zager JS, Lyman GH (2017) Sentinel lymph node biopsy and management of regional lymph nodes in melanoma: American Society of Clinical Oncology and Society of Surgical Oncology Clinical Practice guideline update. J Clin Oncol: 36(4):399–413

    Article  PubMed  Google Scholar 

  • Wright BE, Scheri RP, Ye X, Faries MB, Turner RR, Essner R, Morton DL (2008) Importance of sentinel lymph node biopsy in patients with thin melanoma. Arch Surg 143(9):892–899; discussion 899–900

    Article  PubMed  PubMed Central  Google Scholar 

  • Yao KA, Hsueh EC, Essner R, Foshag LJ, Wanek LA, Morton DL (2003) Is sentinel lymph node mapping indicated for isolated local and in-transit recurrent melanoma? Ann Surg 238(5):743–7.

    Article  PubMed  PubMed Central  Google Scholar 

  • Yokota K, Sawada M, Matsumoto T, Hasegawa Y, Kono M, Akiyama M (2015) Lymphatic flow is mostly preserved after sentinel lymph node biopsy in primary cutaneous malignant melanoma. J Dermatol Sci 78(2):101–107

    Article  PubMed  Google Scholar 

  • Zager JS, Hochwald SN, Marzban SS, Francois R, Law KM, Davis AH, Messina JL, Vincek V, Mitchell C, Church A, Copeland EM, Sondak VK, Grobmyer SR (2011a) Shave biopsy is a safe and accurate method for the initial evaluation of melanoma. J Am Coll Surg 212(4):454–460; discussion 460–452

    Article  PubMed  PubMed Central  Google Scholar 

  • Zager JS, Puleo CA, Sondak VK (2011b) What is the significance of the in transit or interval sentinel node in melanoma? Ann Surg Oncol 18(12):3232–3234

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Cedars Sinai Medical Center, The Angeles Clinic and Research Institute, Los Angeles, CA, USA

    Mark B. Faries

  2. Departments of Pathology, Laboratory Medicine and Surgery, David Geffen School of Medicine at UCLA and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA

    Alistair J. Cochran

  3. Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    Michael McLemore

  4. Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA

    Vernon K. Sondak

  5. Department of Surgery, Geisel School of Medicine at Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA

    Sandra L. Wong

  6. Melanoma Institute Australia, Faculty of Medicine and Health,Central Clinical Schools, The University of Sydney, Sydney, NSW, Australia

    John F. Thompson

  7. Department of Melanoma and Surgical Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia

    John F. Thompson

Authors
  1. Mark B. Faries
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  2. Alistair J. Cochran
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  3. Michael McLemore
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  4. Vernon K. Sondak
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  5. Sandra L. Wong
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  6. John F. Thompson
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Corresponding author

Correspondence to Mark B. Faries .

Editor information

Editors and Affiliations

  1. Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Charles M. Balch

  2. Department of Oncology, Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, DC, USA

    Michael B. Atkins

  3. Centre for Dermatooncology, Department of Dermatology, Eberhard Karls University, Tuebingen, Germany

    Claus Garbe

  4. Departments of Surgical Oncology and Cancer Biology, Melanoma and Skin Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Jeffrey E. Gershenwald

  5. Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Allan C. Halpern

  6. Departments of Medicine, Dermatology, and Translational Science, University of Pittsburgh and UPMC Hillman Cancer Center, Pittsburgh, PA, USA

    John M. Kirkwood

  7. Divisions of Cancer Medicine and Research, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia

    Grant A. McArthur

  8. Melanoma Institute Australia, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia

    John F. Thompson

  9. Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Arthur J. Sober

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Faries, M.B., Cochran, A.J., McLemore, M., Sondak, V.K., Wong, S.L., Thompson, J.F. (2020). Biopsy of the Sentinel Lymph Node. In: Balch, C., et al. Cutaneous Melanoma. Springer, Cham. https://doi.org/10.1007/978-3-030-05070-2_51

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  • DOI: https://doi.org/10.1007/978-3-030-05070-2_51

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  • Online ISBN: 978-3-030-05070-2

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