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Epidemiology of Epilepsies in Developed Countries

  • Christine Linehan
  • Mike Kerr

Short Description

Epidemiological investigations provide important insights into the distribution of and burden imposed by disease. As such, these data should be pivotal in aiding the understanding of disease and thus improving treatment. In particular, epidemiological data can drive the appropriate delivery of health services. Unfortunately, this is an ideal rarely matched in practice.

The collection of epidemiological data in the epilepsies poses certain challenges. Some are specific to epilepsies such as definition, the complex range of etiologies, and the remitting nature of the condition. Others are common to many disease areas, such as ensuring adequate representation through true population survey rather than service-specific populations.

This chapter focuses on developed countries, in themselves a group with definitional challenges. These will be considered to reflect a group of countries linked by a high level of per capita income and industrialization. The exploration of...

Keywords

Intellectual Disability Central Nervous System Disease Case Ascertainment Epilepsy Syndrome Lennox Gastaut Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations

DALYs

Disability-adjusted life years

ILAE

International League Against Epilepsy

AED

Antiepileptic drug

References

  1. Annegers J (2004) Epilepsy. In: Nelson L, Tanner C, Van Den Eeden S, McGuire V (eds) Neuroepidemiology: from principles to practice. Oxford University PressGoogle Scholar
  2. Avanzini G, Beghi E, de boer H, Engle J, Sander JW, Wolf P (2006) Epilepsy, A Public Health Approach in World Health Organisation, Neurological Disorders Public Health Challenges. World Health Organization, Geneva, pp 56–69, 28 February, 2009, http://www.who.int/mental_health/neurology/neurological_disorders_report_web.pdf
  3. Banerjee PN, Hauser WA (2007) Incidence and prevalence. In: Engel J Jr, Pedley TA (eds) Epilepsy: a comprehensive textbook, 2nd edn. Lippincott Williams & Wilkins, USGoogle Scholar
  4. Benn EKT, Hauser WA, Shih T, Leary L, Bagiella E, Dayan P, Green R, Andrews H, Thurman DJ, Hesdorffer DC (2008) Estimating the incidence of first unprovoked seizure and newly diagnosed epilepsy in the low-income urban community of Northern Manhattan, New York City. Epilepsia 49:1431–1439CrossRefPubMedGoogle Scholar
  5. Brodtkorb E, Sjaastad O (2008) Epilepsy prevalence by individual interview in a Norwegian community. Seizure 17:646–650CrossRefPubMedGoogle Scholar
  6. Christensen J, Vestergaard M, Pedersen MG, Pedersen CB, Olsen J, Sidenius P (2007) Incidence and prevalence of epilepsy in Denmark. Epilepsy Res 76:60–65CrossRefPubMedGoogle Scholar
  7. Commission on Epidemiology and Prognosis, International League Against Epilepsy (1993)Guidelines for epidemiologic studies on epilepsy. Epilepsia 34:592–596CrossRefGoogle Scholar
  8. Fisher RS, Leppik I (2008) Debate: when does a seizure imply epilepsy? Epilepsia 49:s9, 7–12CrossRefPubMedGoogle Scholar
  9. Fisher RS, Boas WE, Blume W, Elger C, Genton P, Lee P, Engel J (2005) Epileptic seizures and epilepsy: definitions proposed by the International League against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia 46:470CrossRefPubMedGoogle Scholar
  10. Forsgren L, Beghi E, Oun A, Sillanpää M (2005) The epidemiology of epilepsy in Europe – a systematic review. Eur J Neurol 12:245–253CrossRefPubMedGoogle Scholar
  11. Forsgren L, Hauser WA, Olafsson E, Sander JWAS, Sillanpää M, Tomson T (2006) Mortality of epilepsy in developed countries: a review. Epilepsia 46:S11, 18–27CrossRefGoogle Scholar
  12. Hauser WA, Annegers JF, Kurland LT (1993) Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935–1984. Epilepsia 34(3):453–468CrossRefPubMedGoogle Scholar
  13. Jallon P, Goumaz M, Haenggeli C, Morabia A (1997) Incidence of first epileptic seizures in the canton of Geneva, Switzerland. Epilepsia 38(5):547–552CrossRefPubMedGoogle Scholar
  14. Kelvin EA, Hesdorffer, DC, Bagiella E, Andrews H, Pedley TA, Shih TT, Leary L, Thurman DJ, Hauser WA (2007) Prevalence of self-reported epilepsy in a multiracial and multiethnic community in New York City. Epilepsy Res 77:141–150CrossRefPubMedGoogle Scholar
  15. Kobau R, Zahran H, Thurman DJ, Zack MM, Henry TR, Schachter SC, Price PH (2008) Epilepsy Surveillance Among Adults – 19 States, Behavioral Risk Factor Surveillance System, 2005. Morb Mortal Wkly Rept 57SS-6:1–20Google Scholar
  16. Kotsopoulos IAW, van Merode T, Kessels FGH, de Krom MCTFM, Knottenerus JA (2002) Systematic review and meta-analysis of incidence studies of epilepsy and unprovoked seizures. Epilepsia 43:1402–1409CrossRefPubMedGoogle Scholar
  17. Kotsopoulos I, de Krom M, Kessels F, Lodder J, Troost J, Twellaar M, van Merode T, Knottnerus A (2005) Incidence of epilepsy and predictive factors of epileptic and non-epileptic seizures. Seizure 14:175–182CrossRefPubMedGoogle Scholar
  18. Meinardi H, Scott RA, Reis R, Sander JW, and ILAE Commission on the Developing World (2001) The treatment gap in epilepsy: The current situation and ways forward. Epilepsia 42:136–149CrossRefPubMedGoogle Scholar
  19. Olafsson E, Ludvigsson P, Gudmundsson G, Hesdorffer D, Kjartansson O, Hauser W (2005) Incidence of unprovoked seizures and epilepsy in Iceland and assessment of the epilepsy syndrome classification; a prospective study. Lancet Neurol 4:627–634CrossRefPubMedGoogle Scholar
  20. World Health Organization (2008) The global burden of disease: 2004 update. World Health Organization, Geneva, 28 February, 2009, http://www.who.int/healthinfo/global_burden_disease/2004_report_update/en/index.html

Copyright information

© Springer-Verlag London Limited 2010

Authors and Affiliations

  • Christine Linehan
    • 1
  • Mike Kerr
    • 2
  1. 1.Centre for Disability Studies, School of PsychologyUniversity College Dublin Ireland
  2. 2.Department of Psychological MedicineSchool of Medicine, Cardiff UniversityCardiffUK

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