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Epileptogenesis and Brain Tumors

  • Rüdiger Köhling
Reference work entry

Short Description

Seizures are a common symptom of brain tumors and in fact complicate the already difficult management of tumor patients. Although the clinical phenomenon is common, the mechanisms of tumor-induced seizures are poorly understood, and they have become a matter of experimental investigations only recently. The essay will give a brief overview over these experimental findings, and will spotlight different hypotheses of brain-tumor-dependent modification of neuronal excitability: In the first part of the article, the general processes governing intrinsic, i.e., cellular, and synaptic, i.e., network, excitability will be delineated. The second part addresses the question of tumor-induced epilepsy. While a number of theories have been put forward during the past decades explaining increased excitability with, e.g., increased intracranial pressure, deafferentation (possibly also a problem arising with tumor surgery) and shifts in synaptic properties, loss of astrocytic gap...

Keywords

Temporal Lobe Epilepsy Febrile Seizure Spatial Buffer Network Excitability Epileptic Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations

BBB

Blood–brain barrier

EAAC1

Expression levels of excitatory amino acid carrier 1

GEFS

Generalized epilepsy with febrile seizures

HCN

Hyperpolarization-activated cyclic nucleotide gated nonspecific

mGluR

Metabotropic glutamate receptor

SMEI

Severe myoclonic epilepsy of infancy

TGF-β

Transforming growth factor-β

TRP

Transient receptor potential

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Copyright information

© Springer-Verlag London Limited 2010

Authors and Affiliations

  • Rüdiger Köhling
    • 1
  1. 1.Institute of PhysiologyUniversity of RostockGertrudenstrasse 9Germany

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