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Abbreviations
- CD:
-
Cortical dysplasia
- NMDA:
-
N-methyl-D-aspartate
- TSC:
-
Tuberous sclerosis complex
- UCLA:
-
University of California Los Angeles
References
Andre VM, Flores-Hernandez J, Cepeda C, Starling AJ, Nguyen ST, Lobo MK, Vinters HV, Levine MS, Mathern GW (2004) NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue. Cerebral Cortex 14:634–646
Andre VM, Wu N, Yamazaki I, Nguyen ST, Fisher RS, Vinters HV, Mathern GW, Levine MS, Cepeda C (2007) Cytomegalic interneurons: a new abnormal cell type in severe pediatric cortical dysplasia. J Neuropathol Exp Neurol 66:491–504
Andre VM, Cepeda C, Vinters HV, Huynh M, Mathern GW, Levine MS (2008) Pyramidal cell responses to gamma-aminobutyric acid differ in type I and type II cortical dysplasia. J Neurosci Res 86:3151–3162
Cepeda C, Hurst RS, Flores-Hernandez J, Hernandez-Echeagaray E, Klapstein GJ, Boylan MK, Calvert CR, Jocoy EL, Nguyen OK, Andre VM, Vinters HV, Ariano MA, Levine MS, Mathern GW (2003) Morphological and electrophysiological characterization of abnormal cell types in pediatric cortical dysplasia. J Neurosci Res 72:472–486
Cepeda C, Andre V, Flores-Hernandez J, Nguyen OK, Wu N, Klapstein GJ, Nguyen ST, Koh S, Vinters HV, Levine M, Mathern GW (2005) Correlations between neuroimaging, electrophysiology and location of cytomegalic neurons and balloon cells, and glutamate/GABA synaptic circuits. Dev Neurosci 27:59–76
Cepeda C, Andre VM, Levine MS, Salamon N, Miyata H, Vinters HV, Mathern GW (2006) Epileptogenesis in pediatric cortical dysplasia: the dysmature cerebral developmental hypothesis. Epilepsy Behav 9:219–235
Cepeda C, Andre VM, Wu N, Yamazaki I, Uzgil B, Vinters HV, Levine MS, Mathern GW (2007) Immature neurons and GABA networks may contribute to epileptogenesis in pediatric cortical dysplasia. Epilepsia 48(Suppl 5):79–85
Cherubini E, Gaiarsa JL, Ben-Ari Y (1991) GABA: an excitatory transmitter in early postnatal life. Trends Neurosci 14:515–519
Dzhala VI, Brumback AC, Staley KJ (2008) Bumetanide enhances phenobarbital efficacy in a neonatal seizure model. Ann Neurol 63:222–235
Harvey AS, Cross JH, Shinnar S, Mathern BW (2008) Defining the spectrum of international practice in pediatric epilepsy surgery patients. Epilepsia 49:146–155
Kerfoot C, Vinters HV, Mathern GW (1999) Cerebral cortical dysplasia: giant neurons show potential for increased excitation and axonal plasticity. Dev Neurosci 21:260–270
Lerner JT, Salamon N, Hauptman JS, Velasco TR, Hemb M, Wu JY, Sankar R, Donald Shields W, Engel J Jr, Fried I, Cepeda C, Andre VM, Levine MS, Miyata H, Yong WH, Vinters HV, Mathern GW (2009) Assessment and surgical outcomes for mild type I and severe type II cortical dysplasia: a critical review and the UCLA experience. Epilepsia 50(6):1310–1335
Mischel PS, Nguyen LP, Vinters HV (1995) Cerebral cortical dysplasia associated with pediatric epilepsy. Review of neuropathologic features and proposal for a grading system. J Neuropathol Exp Neurol 54:137–153
Owens DF, Kriegstein AR (2002) Is there more to GABA than synaptic inhibition? Nat Rev Neurosci 3:715–727
Palmini A, Najm I, Avanzini G, Babb T, Guerrini R, Foldvary-Schaefer N, Jackson G, Luders HO, Prayson R, Spreafico R, Vinters HV (2004) Terminology and classification of the cortical dysplasias. Neurology 62:S2–S8
Salamon N, Kung J, Shaw SJ, Koo J, Koh S, Wu JY, Lerner JT, Sankar R, Shields WD, Engel J Jr, Fried I, Miyata H, Yong WH, Vinters HV, Mathern GW (2008) FDG-PET/MRI coregistration improves detection of cortical dysplasia in patients with epilepsy. Neurology 71:1594–1601
Schwartzkroin PA, Walsh CA (2000) Cortical malformations and epilepsy. Ment Retard Dev Disabil Res Rev 6:268–280
Taylor DC, Falconer MA, Bruton CJ, Corsellis JA (1971) Focal dysplasia of the cerebral cortex in epilepsy. J Neurol Neurosurg Psychiatry 34:369–387
Acknowledgment
The authors would like to thank the young patients and their parents for allowing use of resected tissue samples for research purposes. We also thank Raymond S. Hurst, Jorge Flores-Hernández, Elizabeth Hernández-Echeagaray, Nanping Wu, Irene Yamazaki, and Marea K. Boylan, for their assistance in electrophysiological data collection and morphological analyses. The expertise and dedication of the UCLA Hospital Pediatric Neurology Staff are also greatly appreciated. This work was supported by NIH grant NS 38992 from the NINDS.
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Cepeda, C., André, V., Vinters, H., Fisher, R., Levine, M., Mathern, G. (2010). Epileptogenesis and Cortical Dysplasias. In: Panayiotopoulos, C.P. (eds) Atlas of Epilepsies. Springer, London. https://doi.org/10.1007/978-1-84882-128-6_46
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DOI: https://doi.org/10.1007/978-1-84882-128-6_46
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