Epileptogenesis and Febrile Seizures
Introduction and Definitions
Febrile seizures occur in children aged 2 months to 5 years and are caused by fever. Although most cases are considered to have no residual effects on the brain, there are certain cases in which individuals go on to develop epilepsy later in life. This chapter discusses factors that contribute to the process of epileptogenesis after febrile seizures. In this review, both basic science and clinical data are presented to elucidate the role of several key factors involved in the development of epilepsy after a febrile seizure.
Etiology or Methods
Febrile seizures are the most common form of seizure in the pediatric population affecting 2–5% of children in North America between the ages of 2 months and 5 years (Berg and Shinnar 1996a). These seizures are precipitated by a febrile illness that can arise from viral or bacterial infections accompanied by a fever of greater than or equal to 38.3°C. Febrile seizures are heterogeneous and can be classified into...