Skip to main content

Epileptogenesis After Ischemic-Hypoxic Encephalopathy

  • Reference work entry
Atlas of Epilepsies
  • 281 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 599.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 899.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Glass HC, Glidden D, Jeremy RJ, Barkovich AJ, Ferriero DM, Miller SP (2009) Clinical neonatal seizures are independently associated with outcome in infants at risk for hypoxic-ischemic brain injury. J Pediatr 155(3):318–323

    Article  PubMed  Google Scholar 

  • Jensen FE, Applegate CD, Holtzman D, Belin TR, Burchfiel JL (1991) Epileptogenic effect of hypoxia in the immature rodent brain. Ann Neurol 29(6):629–637

    Article  CAS  PubMed  Google Scholar 

  • Jensen FE, Holmes G, Lombroso CT, Blume H, Firkusny I (1992) Age-dependent long term changes in seizure susceptibility and neurobehavior following hypoxia in the rat. Epilepsia 33(6):971–980

    Article  CAS  PubMed  Google Scholar 

  • Kadam SD, Dudek FE (2007) Neuropathological features of a rat model for perinatal hypoxic-ischemic encephalopathy associated with epilepsy. J Comp Neurol 505:716–737

    Article  PubMed  Google Scholar 

  • Magee JC, Johnston D (2005) Plasticity of dendritic function. Curr Opin Neurobiol 15:334–342

    Article  CAS  PubMed  Google Scholar 

  • Mikati MA, Zeinieh MP, Kurdi RM, Harb SA, El Hokayem JA, Daderian RH, Shamseddine A, Obeid M, Bitar FF, El Sabban M (2005) Long term effects of acute and of chronic hypoxia on behavior and on hippocampal histology in the developing brain. Dev Brain Res 157:98–102

    Article  CAS  Google Scholar 

  • Rakhade SN, Hyunh T, Marya N, Chang M, Jensen FE (2008a) Early life hypoxia-induced seizures lead to spontaneous epilepsy in a rodent model. Epilepsia 49(Suppl 7):327 (Abstract)

    Google Scholar 

  • Rakhade SN, Zhou C, Aujla PK, Fishman R, Sucher NJ, Jensen FE (2008b) Early alterations of AMPA receptors mediate synaptic potentiation induced by neonatal seizures. J Neurosci 28(32):7979–7990

    Article  CAS  PubMed  Google Scholar 

  • Rakhade SN, Jensen FE (2009) Epileptogenesis in the immature brain: emerging mechanisms. Nat Rev Neurol 5:380–391

    Article  CAS  PubMed  Google Scholar 

  • Sanchez RM, Jensen FE (2001) Maturational aspects of epilepsy mechanisms and consequences for the immature brain. Epilepsia 42(5):577–585

    Article  CAS  PubMed  Google Scholar 

  • Sanchez RM, Koh S, Rio C, Wang C, Lamperti ED, Sharma D, Corfas G, Jensen FE (2001) Decreased GluR2 expression and enhanced epileptogenesis in immature rat hippocampus following perinatal hypoxia-induced seizures. J Neurosci 21(20):8154–8163

    CAS  PubMed  Google Scholar 

  • Sanchez RM, Dai W, Lippman JJ, Levada R, Jensen FE (2005) AMPA/kainate receptor-mediated downregulation of GABAergic synaptic transmission by calcineurin following seizures in the developing brain. J Neurosci 25(13):3442–3451

    Article  CAS  PubMed  Google Scholar 

  • Sanchez RM, Jensen FE (2006) Modeling hypoxia-induced seizures and hypoxic encephalopathy in the neonatal period. In: Pitkanen A, Moshe SL, Schwartzkroin PA (eds) Models of seizures and epilepsy, Elsevier, USA, pp 323–331

    Chapter  Google Scholar 

  • Sanchez RM, Justice JA, Zhang K (2007) Persistently decreased basal synaptic inhibition of hippocampal CA1 pyramidal neurons after neonatal hypoxia-induced seizures. Dev Neurosci 29(1–2):159–167

    Article  CAS  PubMed  Google Scholar 

  • Shah MM, Anderson AE, Leung V, Lin X, Johnston D (2004) Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons. Neuron 44(3):495–508

    Article  CAS  PubMed  Google Scholar 

  • Vannucci RC, Vannucci SJ (2005) Perinatal hypoxic-ischemic brain damage: evolution of an animal model. Dev Neurosci 27:81–86

    Article  CAS  PubMed  Google Scholar 

  • Volpe JJ (2008) Neurology of the newborn, 5th edn. Saunders Elsevier, Philadelphia

    Google Scholar 

  • Williams PA, Dou P, Dudek FE (2004) Epilepsy and synaptic reorganization in a perinatal rat model of hypoxia-ischemia. Epilepsia 45(10):1210–1218

    Article  PubMed  Google Scholar 

  • Yager JY, Ashwal S (2009) Animal models of hypoxic-ischemic brain damage. Pediatr Neurol 40:156–167

    Article  PubMed  Google Scholar 

  • Zhang K, Peng B, Sanchez RM (2006) Decreased Ih in hippocampal area CA1 pyramidal neurons after perinatal seizure-inducing hypoxia. Epilepsia 47(6):1023–1028

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag London Limited

About this entry

Cite this entry

Sanchez, R. (2010). Epileptogenesis After Ischemic-Hypoxic Encephalopathy. In: Panayiotopoulos, C.P. (eds) Atlas of Epilepsies. Springer, London. https://doi.org/10.1007/978-1-84882-128-6_44

Download citation

  • DOI: https://doi.org/10.1007/978-1-84882-128-6_44

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84882-127-9

  • Online ISBN: 978-1-84882-128-6

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics