Epileptogenesis After Traumatic Brain Injury
Traumatic brain injury (TBI) is one of the most significant health epidemics of our time. Every 21 s, one person in the USA sustains a TBI, and it is estimated that TBI annually affects about 1.5 million Americans. TBI is the leading cause of death among young adults (<45 years) and one of the major causes of disability in the overall population. TBI is estimated to cause 10–20% of all symptomatic epilepsies (Annegers et al. 1998). It is estimated that in the European Union (EU) and USA, at least 0.5 million surviving individuals live with posttraumatic epilepsy (PTE).
The 30-year cumulative incidence of epilepsy is 2.1% for mild (loss of consciousness or amnesia <30 min), 4.2% for moderate (loss of consciousness 30 min–24 h or skull fracture), and 16.7% for severe (with loss of consciousness or amnesia >24 h, subdural hematoma, or brain contusion) injuries (Annegers et al. 1998). Some TBI patients present with penetrating head injury (e.g., bullet wounds), of which up to...
KeywordsTraumatic Brain Injury Closed Head Injury Control Cortical Impact Spontaneous Seizure Brain Injury Model
List of Abbreviations
Blood brain barrier
Controlled cortical impact
Lateral fluid-percussion injury
Traumatic brain injury
- Kochanek P, Vagni V, Janesko K, Washington CB, Crumrine P, Garman R, Jenkins L, Clark R, Homanics G, Dixon E, Schnermann J, Jackson E (2006) Adenosine A1 receptor knockout mice develop lethal status epilepticus after experimental traumatic brain injury. J Cereb Blood Flow Metab 26:565–575CrossRefPubMedGoogle Scholar
- Morales DM, Marklund N, Lebold D, Thompson HJ, Pitkanen A, Maxwell WL, Longhi L, Laurer H, Maegele M, Neugebauer E, Graham DI, Stocchetti N, McIntosh TK (2005) Experimental models of traumatic brain injury: do we really need to build a better mousetrap? Neuroscience 136:971–989CrossRefPubMedGoogle Scholar