Induced and Acquired Epileptogenicity in Animal Models
This chapter discusses well-established animal models used to study the basic mechanisms of ictogenesis (i.e., models of seizures) and those developed to investigate the process of epileptogenesis (models of chronic epilepsy). For genetic models ( Genetic Animal Models of Epileptic Seizures) animal models have recently been extensively described and critically revised (Pitkänen 2006), and are further analyzed in other chapters of the Atlas.
Models of Seizures
This section includes the most common procedures utilized to generate seizures by acute electrical or pharmacological manipulations.
Drug-Induced Acute Models of Generalized Seizures
KeywordsStatus Epilepticus Temporal Lobe Epilepsy Kainic Acid Febrile Seizure Clonic Seizure
- Ben-Ari Y, Tremblay E, Otterson OP (1980) Injection of kainic acid in the amygdaloid complex of the rat: an electroencephalographic, clinical and histological study in relation to the pathology of epilepsy. Neuroscience 5:15–52Google Scholar
- Colacitti C, Sancini G, DeBiasi S, Franceschetti S, Caputi A, Frassoni C, Cattabeni F, Avanzini G, Spreafico R, Di Luca M, Battaglia G (1999) Prenatal methylazoxymethanol treatment in rats produces brain abnormalities with morphological similarities to human developmental brain dysgeneses. J Neuropathol Exp Neurol 58:92–106CrossRefPubMedGoogle Scholar
- Dvorak K, Feit J (1977) Migration of neuroblasts through partial necrosis of the cerebral cortex in newborn rats-contribution to the problems of morphological development and developmental period of cerebral microgyria. Histological and autoradiographical study. Acta Neuropathol 38:203–212CrossRefPubMedGoogle Scholar
- Fabene PF, Navarro MG, Martinello M, Rossi B, Merigo F, Ottoboni L, Bach S, Angiari S, Benati D, Chakir A, Zanetti L, Schio F, Osculati A, Marzola P, Nicolato E, Homeister JW, Xia L, Lowe JB, McEver RP, Osculati F, Sbarbati A, Butcher EC, Constantin G (2008) A role for leukocyte-endothelial adhesion mechanisms in epilepsy. Nat Med 14:1377–1383CrossRefPubMedGoogle Scholar
- Morales DM, Marklund N, Lebold D, Thompson HJ, Pitkanen A, Maxwell WL, Longhi L, Laurer H, Maegele M, Neugebauer E, Graham DI, Stocchetti N, McIntosh TK (2005) Experimental models of traumatic brain injury: do we really need to build a better mousetrap? Neuroscience 136:971–989CrossRefPubMedGoogle Scholar