Epileptogenesis and Animal Models of Epilepsies: Overview

  • Aristea S. Galanopoulou
  • Solomon L. Moshé
Reference work entry
Understanding the mechanisms by which sometimes trivial insults lead to the development of a seizure and subsequently the occurrence of epilepsy that may or may not be responding to medication is a hot topic for debate. Figure 38-1depicts the various stages of the epileptic process. It should be clearly understood that the occurrence of one seizure does not necessarily mean that epilepsy will occur as 5% of the population may have one seizure in their lifetime. Thus epileptogenesis can be defined as the development and expansion of brain regions that are capable of generating either acute seizures, but more important in terms of epilepsy, chronic, recurrent, and spontaneous behavioral seizures associated with electrographic discharges. Therefore, there are three aspects. First, the initial expression of a seizure which can be modeled with a plethora of acute models of epilepsy induced either by pharmacologic means or by electrical stimulation. These are extensively summarized in the...


Traumatic Brain Injury Status Epilepticus Epileptic Seizure Febrile Seizure Cortical Dysplasia 
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Supported by NINDS grants NS020253, NS45243, NS048856, NS058303, NINDS/NICHD grant NS62947, grants from PACE and IRSF, and the Heffer Family Medical Foundation. SLM is the recipient of the Martin A. and Emily L. Fisher fellowship in Neurology and Pediatrics.


  1. Gurkoff GG, Giza CC, Shin D, Auvin S, Sankar R, Hovda DA (2009) Acute neuroprotection to pilocarpine-induced seizures is not sustained after traumatic brain injury in the developing rat. Neuroscience 164(2):862–876CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag London Limited 2010

Authors and Affiliations

  • Aristea S. Galanopoulou
    • 1
  • Solomon L. Moshé
    • 2
  1. 1.Departments of Neurology and NeuroscienceAlbert Einstein College of Medicine, Yeshiva University Jack and Pearl Resnick CampusBronxUSA
  2. 2.Departments of Neurology, Neuroscience & PediatricsAlbert Einstein College of MedicineBronxUSA

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