Pathophysiology of Termination of Seizures

  • Stephen Fried
  • Fred A. Lado
Reference work entry

Introduction and Definitions

The pathophysiology of seizure termination is often overshadowed by the factors contributing to seizure initiation and propagation. Nevertheless, seizure termination is a critical factor in the return to the interictal or postictal state. The mechanisms involved in this process range in scale from the regulation of transmembrane potentials, to local neuronal network interactions, to mediation from relatively remote structures such as the brain stem and basal ganglia. This chapter discusses the roles of mechanisms that are involved in seizure termination in successively increasing “size scales,” subdivided into (1) those acting at the level of single neurons, (2) those acting on a local network of neurons, and (3) those acting remotely to limit excitation and seizure spread.

Structural and Functional Correlates

Mechanisms Acting at the Level of Single Neurons

Several mechanisms are involved in seizure termination at the neuronal level ( Fig. 37-1). The first...


Status Epilepticus Silent Period Seizure Termination Seizure Discharge Seizure Onset Zone 
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List of Abbreviations


Adenosine triphosphate


Excitatory post-synaptic current






Subthalamic nucleus


Substantia nigra pars reticulata


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Copyright information

© Springer-Verlag London Limited 2010

Authors and Affiliations

  • Stephen Fried
    • 1
  • Fred A. Lado
    • 1
  1. 1.Department of NeurologyMontefiore Medical Center/Albert Einstein College of MedicineBronxUSA

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