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Pathophysiology of Status Epilepticus: Experimental Data

  • Uwe Heinemann
  • Martin Holtkamp
Reference work entry

Introduction and Definitions

Some 150 years ago, Armand Trousseau from Paris recognized that during “status epilepticus, something happens [in the brain] that requires an explanation” (Trousseau 1868). In spite of recent progress, treatment success is still limited, since more than 30% of patients develop refractory status epilepticus (SE) that is often associated with severe neuronal and clinical sequelae. There is a long-lasting debate on how long seizure activity should last to define SE (Chen and Wasterlain 2006). While in epidemiological studies, the definition of SE is commonly based on a minimal seizure duration of 30 min (Wasterlain and Chen 2006), in clinical practice, anticonvulsant treatment should be initiated in both generalized convulsive and non-convulsive forms of SE 5 min after onset of seizure activity (Chen and Wasterlain 2006; Meierkord and Holtkamp 2007). However, in some conditions, even shorter periods of seizure activity can result in neuronal damage. To better...

Keywords

Status Epilepticus GABAA Receptor Slice Culture Refractory Status Epilepticus Radical Oxygen Species 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations

AED

Antiepileptic drug

AMPA

α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

BBB

Blood brain barrier

GABA

γ-Amino-butyric acid

NMDA

N-methyl-d-aspartate

ROS

Radical oxygen species

ROS

Reactive oxygen species

SE

Status epilepticus

SSSE

Self-sustaining status epilepticus

TGF-βR

Transforming growth factor β receptor

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Copyright information

© Springer-Verlag London Limited 2010

Authors and Affiliations

  • Uwe Heinemann
    • 1
  • Martin Holtkamp
    • 2
  1. 1.Institute of Neurophysiology, CharitéUniversitätsmedizin BerlinTucholskystr. 2Germany
  2. 2.Department of Neurology, CharitéUniversitätsmedizin BerlinSchumannstrasse 20/21Germany

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