Pathophysiology of Limbic Epileptic Seizures
Pathophysiology in any network of neurons often involves multidimensional factors, including brain injuries, tumors, malformations, and channelopathies as well as genetic predispositions, environmental triggers, and many more. Alterations to one or more of these factors away from normalcy do not always create measurable changes reflective of pathology, but depending upon where in the nervous system they exist and in whom they occur, they often do. The most common outcome of such changes is epilepsy and because of its involvement in memory, emotionality, social interaction, and other processes, one of the most vulnerable networks in the central nervous system for generating behavioral pathologies when deviated from its normal expression is the limbic system.
The limbic system was first outlined by Broca (1878) to identify various structures that surround the brain stem and form the border of the ventricular system. He believed that these structures were primarily...
KeywordsAttention Deficit Hyperactivity Disorder Attention Deficit Hyperactivity Disorder Epileptic Seizure Temporal Lobe Epilepsy Focal Seizure
- Broca P (1878) Anatomie comparée des circonvulutions cerebrales. Le grand lobe limbique et al scissure limbique dans le serie des mammiferes. Rev Anthropol Ser 2(1):385–498Google Scholar
- Engel J Jr (1989) Seizures and Epilepsy. FA Davis, PhiladelphiaGoogle Scholar
- Engel J Jr, Williamson PD (2008) Limbic Seizures. In: Engel J Jr, Pedley TA (eds) Epilepsy: a comprehensive textbook, Lippincott Williams & Wilkins, Philadelphia, pp 541–552Google Scholar
- McIntyre DC, Gilby KL (2007) Genetically seizure-prone or seizure-resistant phenotypes and their associated behavioral comorbidities. Epilepsia (Suppl 9):30–32 [Review]Google Scholar
- McIntyre DC, Kelly ME, Staines WA (2006) Pathophysiology of seizure circuitry in status epilepticus. In: Wasterlain CG, Treiman DM (eds) Status epilepticus: mechanisms and management, MIT Press Cambridge, MA, pp 229–238Google Scholar
- McIntyre DC, Schwartzkroin PA (2008) Limbic anatomy and physiology. In: Engel J Jr, Pedly TA (eds) Epilepsy: a comprehensive textbook, Lippincott Williams & Wilkins, Philadelphia, pp 337–352Google Scholar
- Papez JW (1937) A proposed mechanism of emotion. Arch Neurol Psychiat 38:725–743Google Scholar
- Weiser HG (1983) Electrophysiological features of psychomotor seizure. A stereoelectrophysiological study of ictal symptoms and chronotopographical seizure patterns including clinical effects of intracerebral stimulation. Butterworths, LondonGoogle Scholar