Factors Modulating Seizure Susceptibility

  • Nicola Marchi
  • Tiziana Granata
  • Damir Janigro
Reference work entry

Short Description

From Seizures to Epilepsies

The occurrence of seizures does not always lead to a diagnosis of epilepsy. Within a life span, 5–10% of the population will have at least one seizure without being considered an epileptic (Shorvon 2005). While the distinction between seizures and epilepsies is clinically well understood, a semantic uncertainty still subsists among basic scientists. Epilepsy research has often failed to fully take into account the important lessons learned from clinicians: this sometimes led to a simplistic modeling of the disease. This gap, if bridged, will unveil novel mechanisms and open a venue for the investigation of new therapeutic approaches.

The relationship between cerebrovascular disease and epilepsy has long been appreciated since Jackson first reported partial seizures in the setting of acute stroke. Indeed, cerebrovascular disease has been found to be one of the most common causes of secondary epilepsy. A crucial factor linking seizures to...


Traumatic Brain Injury Status Epilepticus Chronic Seizure Experimental Status Epilepticus Decrease Seizure Threshold 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag London Limited 2010

Authors and Affiliations

  • Nicola Marchi
    • 1
    • 3
  • Tiziana Granata
    • 4
  • Damir Janigro
    • 1
    • 2
    • 3
  1. 1.Cerebrovascular Research Cell BiologyCleveland ClinicClevelandUSA
  2. 2.Molecular MedicineCleveland ClinicClevelandUSA
  3. 3.Neurological SurgeryCleveland ClinicClevelandUSA
  4. 4.Neurological Institute Carlo BestaMilanItaly

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