Factors Modulating Seizure Susceptibility
From Seizures to Epilepsies
The occurrence of seizures does not always lead to a diagnosis of epilepsy. Within a life span, 5–10% of the population will have at least one seizure without being considered an epileptic (Shorvon 2005). While the distinction between seizures and epilepsies is clinically well understood, a semantic uncertainty still subsists among basic scientists. Epilepsy research has often failed to fully take into account the important lessons learned from clinicians: this sometimes led to a simplistic modeling of the disease. This gap, if bridged, will unveil novel mechanisms and open a venue for the investigation of new therapeutic approaches.
The relationship between cerebrovascular disease and epilepsy has long been appreciated since Jackson first reported partial seizures in the setting of acute stroke. Indeed, cerebrovascular disease has been found to be one of the most common causes of secondary epilepsy. A crucial factor linking seizures to...
KeywordsTraumatic Brain Injury Status Epilepticus Chronic Seizure Experimental Status Epilepticus Decrease Seizure Threshold
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