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Factors Modulating Seizure Susceptibility

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Atlas of Epilepsies

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From Seizures to Epilepsies

The occurrence of seizures does not always lead to a diagnosis of epilepsy. Within a life span, 5–10% of the population will have at least one seizure without being considered an epileptic (Shorvon 2005). While the distinction between seizures and epilepsies is clinically well understood, a semantic uncertainty still subsists among basic scientists. Epilepsy research has often failed to fully take into account the important lessons learned from clinicians: this sometimes led to a simplistic modeling of the disease. This gap, if bridged, will unveil novel mechanisms and open a venue for the investigation of new therapeutic approaches.

The relationship between cerebrovascular disease and epilepsy has long been appreciated since Jackson first reported partial seizures in the setting of acute stroke. Indeed, cerebrovascular disease has been found to be one of the most common causes of secondary epilepsy. A crucial factor linking seizures to...

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Author information

Authors and Affiliations

  1. Cerebrovascular Research Cell Biology, Cleveland Clinic, 9500 Euclid Ave, 44195, Cleveland, OH, USA

    Nicola Marchi & Damir Janigro

  2. Molecular Medicine, Cleveland Clinic, 9500 Euclid Ave, 44195, Cleveland, OH, USA

    Damir Janigro

  3. Neurological Surgery, Cleveland Clinic, 9500 Euclid Ave, 44195, Cleveland, OH, USA

    Nicola Marchi & Damir Janigro

  4. Neurological Institute Carlo Besta, Milan, Italy

    Tiziana Granata

Authors
  1. Nicola Marchi
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  2. Tiziana Granata
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  3. Damir Janigro
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Editor information

Editors and Affiliations

  1. Department of Clinical Neurophysiology and Epilepsies, St. Thomas' Hospital, London, SE1 7EH, UK

    C. P. Panayiotopoulos PhD, FRCP (MD) (MD)

  2. Department of Neurosciences, John Radcliffe Hospital, Oxford, OX3 9DU, UK

    C. P. Panayiotopoulos PhD, FRCP (MD) (MD)

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© 2010 Springer-Verlag London Limited

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Marchi, N., Granata, T., Janigro, D. (2010). Factors Modulating Seizure Susceptibility. In: Panayiotopoulos, C.P. (eds) Atlas of Epilepsies. Springer, London. https://doi.org/10.1007/978-1-84882-128-6_26

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  • DOI: https://doi.org/10.1007/978-1-84882-128-6_26

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84882-127-9

  • Online ISBN: 978-1-84882-128-6

  • eBook Packages: MedicineReference Module Medicine

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