Skip to main content
SpringerLink
Log in

Peptic Ulcer Disease and Helicobacter Pylori

  • Reference work entry
General Surgery

  • 275 Accesses

Pearls and Pitfalls

  • Helicobacter pylori plays a prominent role in upper gastrointestinal disease worldwide.

  • More than 50% of the world's population is infected with the organism; in those infected individuals, the estimated lifetime risk for ulcer disease and gastric cancer are 15% and 0.5–2%, respectively.

  • Whether an individual will develop H. pylori-related disease depends on bacterial virulence, host genetic susceptibility, and environmental factors.

  • There appears to be a negative association between H. pylori infection and gastroesophageal reflux disease.

  • H. pylori-related duodenal and gastric ulcers are associated with antral-predominant and diffuse gastritis, respectively.

  • Twenty percent of patients are asymptomatic until complications develop.

  • First-line eradication treatment involves triple therapy with a proton pump inhibitor or ranitidine bismuth citrate, and two antimicrobial agents like clarithromycin, amoxicillin, or metronidazole. Medications are given twice daily for...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 229.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Selected Readings

  • Chu KM, Kwok KF, Law SYK, et al. (1999) Helicobacter pylori status and endoscopy follow-up of patients having a past history of perforated duodenal ulcer. Gastrointest Endosc 50:58–62

    Article  PubMed  CAS  Google Scholar 

  • Chu KM, Kwok KF, Law S, Wong KH (2005) Patients with Helicobacter pylori positive and negative duodenal ulcers have distinct clinical characteristics. World J Gastroenterol 11:3518–3522

    PubMed  Google Scholar 

  • Marshall B (1983) Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1:1273–1275

    Google Scholar 

  • McColl KEL (1997) Pathophysiology of duodenal ulcer disease. Eur J Gastroenterol Hepatol 9 (Suppl 1):S9–S12

    Article  PubMed  Google Scholar 

  • Peterson WL, Fendrick AM, Cave DR, et al. (2000) Helicobacter pylori-related disease: guidelines for testing and treatment. Arch Intern Med 160:1285–1291

    Article  PubMed  CAS  Google Scholar 

  • Walsh JH, Peterson WL (1995) The treatment of Helicobacter pylori infection in the management of peptic ulcer disease. N Engl J Med 333:984–991

    Article  PubMed  CAS  Google Scholar 

  • Warren JR (1983) Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1:1273

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Professor of Surgery Chief of Division of Upper Gastrointestinal Surgery Department of Surgery, The University of Hong Kong, Queen Mary Hospital Pokfulam Road, Hong Kong, China

    Kent-Man Chu

Authors
  1. Kent-Man Chu
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Surgery, Deputy Director, Comprehensive Cancer Center University of Alabama School of Medicine, Birmingham, AL, USA

    Kirby I. Bland MD (Fay Fletcher Kerner Professor and Chairman) (Fay Fletcher Kerner Professor and Chairman)

  2. Department of General and Visceral Surgery, University of Heidelberg, Heidelberg, Germany

    Markus W. Büchler MD (Professor of Surgery and Chairman) (Professor of Surgery and Chairman)

  3. Department of Surgery, University Hospital, Santiago, Chile

    Attila Csendes MD, FACS (Hon) (Professor of Surgery and Chairman) (Professor of Surgery and Chairman)

  4. James C. Mason Professor of Surgery Department of Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA

    Michael G. Sarr MD

  5. Department of Clinical and Surgical Sciences, The University of Edinburgh Royal Infirmary of Edinburgh, Edinburgh, UK

    O. James Garden MBChB, MD, FRCS (Ed), FRCP (Ed), FRACS (Hon) (Regius Professor of Clinical Surgery) (Regius Professor of Clinical Surgery)

  6. Department of Surgery, The University of Hong Kong Queen Mary Hospital, Hong Kong, China

    John Wong BSc (Med (Syd)), MBBS (Syd), PhD (Syd), MD (Hon (Syd)), FRACS, FRCS (Edin), FRCS (Glasg), FACS (Hon) (Chair Professor) (Chair Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer Science+Business Media, LLC

About this entry

Cite this entry

Chu, KM. (2009). Peptic Ulcer Disease and Helicobacter Pylori . In: Bland, K.I., Büchler, M.W., Csendes, A., Sarr, M.G., Garden, O.J., Wong, J. (eds) General Surgery. Springer, London. https://doi.org/10.1007/978-1-84628-833-3_47

Download citation

  • DOI: https://doi.org/10.1007/978-1-84628-833-3_47

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84628-832-6

  • Online ISBN: 978-1-84628-833-3

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation