Skip to main content

Achalasia: Chagas' Disease

  • Reference work entry
General Surgery

Pearls and Pitfalls

  • Chagas' disease is related etiologically to the protozoan hemoflagellate, Trypanossoma cruzi with destruction of Meissner’s and Auerbach’s plexuses of the esophagus.

  • Esophagogram and manometry of the esophagus are fundamental for the diagnosis and allow classification into three stages: incipient, non-advanced, and advanced (end stage).

  • Non-operative treatment provides only temporary relief of dysphagia.

  • Cardiomyotomy with partial fundoplication is indicated in the non-advanced variant of achalasia and provides relief of dysphagia.

  • Motility studies confirm a significant decrease of LES pressure after both types of operation, open or laparoscopic.

  • The benefits of minimally invasive surgery include reduction of pain, short hospital stay, and more rapid return to normal activities.

  • Advanced achalasia is treated by transhiatal esophagectomy without thoracotomy and cervical gastroplasty.

  • The occurrence of Barrett's epithelium in the esophageal stump will prompt annual...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 229.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Selected Readings

  • Bettarello A, Pinotti HW (1976) Oesophageal involvement in Chagas' disease. Clin Gastroentrol 5:103–117

    Google Scholar 

  • Cecconello I (1998) Long-term evaluation of gastroplasty in achalasia. In: Siewert R, Holsher AH (eds) Diseases of the esophagus. Springer-Verlag, Berlin, pp. 975–978

    Google Scholar 

  • Cecconello I, Mariano da Rocha J, Zilberstein B, et al. (1993) Reflux esophagitis and development of ectopic columnar epithelium in the esophageal stump after gastric transposition. In: Nabeia K, Hanaoka T, Nogami T (eds) Recent advances in diseases of the esophagus. Springer-Verlag, Berlin

    Google Scholar 

  • Cunha-Neto E (2001) Understanding the immunopathogenesis of Chagas disease: perspectives for the new millennium. In: Pinotti HW, Cecconello I, Felix VN, Oliveira MA (eds) Recent advances in disease of the esophagus. Manduzzi Editore, Bologna, pp. 197–204

    Google Scholar 

  • da Silveira AB, Arantes RM, Vago AR, et al. (2005) Comparative study of the presence of Trypanosoma cruzi kDNA, inflammation and denervation in chagasic patients with and without megaesophagus. Parasitology 131:627–634

    Article  PubMed  CAS  Google Scholar 

  • Felix VN (1998) Achalasia: a prospective results of dilatation and myotomy. Hepatogastroenterol 45:97–108

    CAS  Google Scholar 

  • Meneguelli UF (2001) Chagasic megaesophagus – historical aspects and present situation in South America. In: Pinotti HW, Cecconello I, Felix VN, Oliveira MA (eds) Recent advances in disease of the esophagus. Manduzzi Editore, Bologna, pp. 197–204

    Google Scholar 

  • Moraes-Filho JP, Bettarello A (1989) Response of the lower esophageal sphincter to pentagastrin on patients with megaesophagus secondary to Chagas' disease. Rev Hosp Clin Fac Med Sao Paulo 44:178–180

    PubMed  CAS  Google Scholar 

  • Pinotti HW (1964) Contribuição para o estudo de fisiopatologia do megaesôfago. Thesis, Faculdade de Medicina da Universidade de São Paulo

    Google Scholar 

  • Pinotti HW. (1988) The basis of its treatment. In: Siewert JR, Holscher AH (eds) Diseases of esophagus. Springer-Verlag, Berlin, pp. 17–19

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer Science+Business Media, LLC

About this entry

Cite this entry

Cecconello, I., Takeda, F.R., Pinotti, H.W. (2009). Achalasia: Chagas' Disease. In: Bland, K.I., Büchler, M.W., Csendes, A., Sarr, M.G., Garden, O.J., Wong, J. (eds) General Surgery. Springer, London. https://doi.org/10.1007/978-1-84628-833-3_41

Download citation

  • DOI: https://doi.org/10.1007/978-1-84628-833-3_41

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84628-832-6

  • Online ISBN: 978-1-84628-833-3

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics