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Pancreatic Cancer pp 1435–1460Cite as

Role of Radiotherapy in Locally Advanced Pancreatic Cancer

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Abstract

Pancreatic cancer carries a poor prognosis regardless of stage, and incidence and death rates are increasing. Pancreatic cancer is divided into four general categories, resectable, borderline resectable, locally advanced/unresectable, and metastatic. Only 15–20% of patients diagnosed with pancreatic cancer have resectable or borderline resectable disease at diagnosis. Most patients are diagnosed with more advanced disease; approximately 30–40% of patients present with locally advanced, unresectable pancreatic cancer (LAPC) at the time of diagnosis, and another 40% have distant metastatic disease. Surgery provides the only chance of cure for patients with pancreatic cancer, but the likelihood of patients with unresectable disease ultimately proceeding to surgical resection is low. The management of these patients with locally advanced, unresectable disease is controversial, and there is no internationally accepted regimen. The data for the use of radiation therapy in the setting of LAPC will be discussed in this chapter.

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Authors and Affiliations

  1. Department of Radiation Oncology, Duke University, Box 3085, Durham, NC, 27710, USA

    Daphna Spiegel, Julian Hong, Manisha Palta, Brian Czito & Christopher Willett

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  1. Daphna Spiegel
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  2. Julian Hong
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  3. Manisha Palta
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  4. Brian Czito
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  5. Christopher Willett
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Correspondence to Manisha Palta .

Editor information

Editors and Affiliations

  1. Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany

    John P. Neoptolemos

  2. Division of Research Department of Surgery and Genomic Sciences and Precision Medicine Center (GSPMC), Medical College of Wisconsin, Milwaukee, Wisconsin, USA

    Raul Urrutia

  3. Division of Medical Oncology, Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA

    James L. Abbruzzese

  4. Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany

    Markus W. Büchler

Section Editor information

  1. Division of Surgery and Oncology, University of Liverpool, Daulby Street, Liverpool, UK

    John Neoptolemos

  2. Mayo Clinic Cancer Center, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA

    Raul A. Urrutia

  3. Duke University Medical Center, Durham, NC, USA

    James L. Abbruzzese

  4. Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany

    Markus W. Büchler

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Spiegel, D., Hong, J., Palta, M., Czito, B., Willett, C. (2018). Role of Radiotherapy in Locally Advanced Pancreatic Cancer. In: Neoptolemos, J., Urrutia, R., Abbruzzese, J., Büchler, M. (eds) Pancreatic Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7193-0_88

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