Pancreatic Cancer pp 1089-1104 | Cite as

Arterial Resection in Pancreatic Cancer

  • Declan F. J. Dunne
  • Jörg Kleeff
  • Vincent S. Yip
  • Christopher Halloran
  • Paula Ghaneh
  • John P. Neoptolemos
Reference work entry


Pancreatic cancer surgery is the only potentially curative approach for this disease and remains a formidable challenge. Better perioperative management, increased experience and advanced surgical techniques, and centralization of care have significantly reduced morbidity and mortality rates of major pancreatic resection. Together with more active and effective chemotherapeutic and radiotherapeutic regimen, this has led to an increase use of resectional procedures in borderline resectable and locally advanced unresectable tumors. Especially for the latter, arterial resection is often necessary to achieve clear margins. However, this approach is currently under debate with higher rates of complications reported. In this chapter, an overview is provided of potential indications and techniques as well as short- and long-term outcomes associated with these procedures.


Pancreatic cancer Arterial resection Appleby procedure Locally advanced Neoadjuvant therapy 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Declan F. J. Dunne
    • 1
  • Jörg Kleeff
    • 3
  • Vincent S. Yip
    • 1
  • Christopher Halloran
    • 2
  • Paula Ghaneh
    • 1
    • 2
  • John P. Neoptolemos
    • 4
  1. 1.Department of SurgeryThe Royal Liverpool and Broadgreen University Hospitals NHS TrustLiverpoolUK
  2. 2.Department of Molecular and Clinical Cancer Medicine, Institute of Translational MedicineUniversity of LiverpoolLiverpoolUK
  3. 3.Department of Visceral, Vascular and Endocrine SurgeryMartin-Luther-University Halle-WittenbergHalle (Saale)Germany
  4. 4.Department of General, Visceral and Transplantation SurgeryUniversity of HeidelbergHeidelbergGermany

Section editors and affiliations

  • James L. Abbruzzese
    • 1
  • Raul A. Urrutia
    • 2
  • John Neoptolemos
    • 3
  • Markus W. Büchler
    • 4
  1. 1.Duke University Medical CenterDurhamUSA
  2. 2.Mayo Clinic Cancer CenterMayo ClinicRochesterUSA
  3. 3.Division of Surgery and OncologyUniversity of LiverpoolLiverpoolUK
  4. 4.Department of General, Visceral and Transplantation SurgeryUniversity of HeidelbergHeidelbergGermany

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