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Pancreatic Cancer pp 1361-1377 | Cite as

Cancer Exosomes for Early Pancreatic Cancer Diagnosis and Role in Metastasis

  • Murray Korc
  • Samantha Deitz McElyea
Reference work entry

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a treatment-recalcitrant and highly metastatic cancer. Recent studies have demonstrated that PDAC is associated with an increased release of small vesicles called exosomes that are ~40 to 130 nanometers in diameter. These exosomes may derive from pancreatic cancer cells, cancer-associated fibroblasts, and infiltrating immune and inflammatory cells. They carry a cargo rich in proteins, lipids, DNA, and microRNAs. Exosomes can modulate the tumor microenvironment, promote pancreatic cancer cell proliferation, invasion, and metastasis, and prime the pre-metastatic niche to facilitate formation of distant metastatic lesions. Components of the exosomal cargo may also serve as diagnostic biomarkers and guide the design of precision medicine strategies. Finally, exosomes have been proposed to act as biological nanoparticles that can be loaded with drugs for therapeutic use.

Keywords

Early diagnosis MicroRNAs Exosomes Metastasis 

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Authors and Affiliations

  1. 1.Departments of Medicine, Biochemistry and Molecular BiologyIndiana University School of Medicine, the Melvin and Bren Simon Cancer Center and the Pancreatic Cancer Signature CenterIndianapolisUSA
  2. 2.Department of MedicineIndiana University Melvin and Bren Simon Cancer CenterIndianapolisUSA

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