Pancreatic Cancer pp 1305-1324 | Cite as
Approaching Pancreatic Cancer Phenotypes via Metabolomics
Abstract
Metabolomics, one of the latest omics’ technologies, focuses on the global, quantitative, and simultaneous measurement of endogenous metabolites in a biological sample. Investigation of either individual metabolites, a panel of metabolites, or a broad metabolite profile (metabolome) can be carried out in cells, tissues, or body fluids. Recent publications indicate that there is an enormous, constantly growing multitude of metabolomics applications in oncology. As a translational research tool, metabolomics provides a link between basic in vitro laboratory data to in vivo preclinical results and clinical oncology and enables systems biology insights. In the present chapter, the current and potential future applications of metabolomics in PDAC research are focused on the clinical aspects of diagnostics.
Keywords
Metabolomics Metabolite profiling Mass spectrometry Nuclear magnetic resonance Metabolism Biomarker Systems biology approach Stable isotope-labeled metabolites Metabolite flux MS-based metabolite imagingReferences
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