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CRM1

  • Reference work entry
  • First Online:
Encyclopedia of AIDS

  • 8 Accesses

Definition

CRM1, chromosome region maintenance 1 protein also known as exportin-1 (XPO1), mediates the export out of the nucleus of cellular proteins with a leucine-rich nuclear export signal (NES, a short 8–15 amino acid hydrophobic motif), such as the HIV-1 Rev and the HTLV-1 Rex proteins, and the transport of small RNA cargoes. The gene for CRM1 is located on chromosome 2p15. CRM1 is widely conserved and is found in species ranging from candida, yeast, drosophila, xenopus, and mammals.

Organization of CRM1 Protein

The CRM1 protein is 1071 amino acids in length (http://www.uniprot.org/uniprot/O14980) (Kudo et al. 1997). It is a member of the karyopherin β family (Moroianu 1998). This family of proteins is involved in many nucleocytoplasmic transport events; the karyopherin proteins are termed either importins or exportins, depending on the direction that they ferry their cargoes. Human CRM1 shares an N-terminal domain (amino acids 46–112) with homology to karyopherin β 1, β 2, β 3,...

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Author information

Authors and Affiliations

  1. Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, 20892-0460, MD, USA

    Venkat R. K. Yedavalli

Authors
  1. Venkat R. K. Yedavalli
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Correspondence to Venkat R. K. Yedavalli .

Editor information

Editors and Affiliations

  1. Department of Cell and Molecular Biology, Northwestern University, Robert H. Lurie Medical Research Center, Chicago, IL, USA

    Thomas J. Hope

  2. VA San Diego Healthcare System and University of California San Diego, La Jolla, CA, USA

    Douglas D. Richman

  3. Department of Medicine, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA

    Mario Stevenson

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Yedavalli, V.R.K. (2018). CRM1. In: Hope, T.J., Richman, D.D., Stevenson, M. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7101-5_78

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  • DOI: https://doi.org/10.1007/978-1-4939-7101-5_78

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-7100-8

  • Online ISBN: 978-1-4939-7101-5

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