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Conjunctival Carcinoma

  • Reference work entry
  • First Online:
Encyclopedia of AIDS

  • 31 Accesses

Definition

Conjunctival carcinoma encompasses several eye neoplasms that include squamous cell carcinoma (SCC) and malignant melanoma. In both cases the patients tend to be older males, often with a significant history of chronic sun exposure. Ocular surface squamous neoplasia (OSSN) is a term used to describe conjunctival or corneal neoplastic growth; it encompasses a range of conditions from simple dysplasia to conjunctival intraepithelial neoplasia (CIN) and invasive SCC. There is evidence that conjunctival squamous cell carcinoma (CSCC) is becoming more common, more aggressive, and affecting more young people, especially women. Immunocompromised patients, including those infected with HIV, are predisposed to developing these neoplasms. There is mounting evidence that one or more infectious agents, especially types of human papillomavirus (HPV), may be involved in the pathogenesis of CSCC, but there is still some uncertainty about the etiologic role of these agents and additional...

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References

  • Ateenyi-Agaba C. Conjunctival squamous-cell carcinoma associated with HIV infection in Kampala, Uganda. Lancet. 1995;345:695–6.

    Article  CAS  PubMed  Google Scholar 

  • Chisi SK, Kollmann MK, Karimurio J. Conjunctival squamous cell carcinoma in patients with human immunodeficiency virus infection seen at two hospitals in Kenya. East Afr Med J. 2006;83:267–70.

    Article  CAS  PubMed  Google Scholar 

  • Feng H, Taylor JL, Benos PV, et al. Human transcriptome subtraction by using short sequence tags to search for tumor viruses in conjunctival carcinoma. J Virol. 2007;81(20):11332–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ferreri AJ, Guidoboni M, Ponzoni M, et al. Evidence for an association between Chlamydia psittaci and ocular adnexal lymphomas. J Natl Cancer Inst. 2004;96:586–94.

    Article  PubMed  Google Scholar 

  • Ferreri AJ, Ponzoni M, Viale E, et al. Association between Helicobacter pylori infection and MALT-type lymphoma of the ocular adnexa: clinical and therapeutic implications. Hematol Oncol. 2006a;24:33–7.

    Article  PubMed  Google Scholar 

  • Ferreri AJ, Ponzoni M, Guidoboni M, et al. Bacteria- eradicating therapy with doxycycline in ocular adnexal MALT lymphoma: a multicenter prospective trial. J Natl Cancer Inst. 2006b;98:1375–82.

    Article  CAS  PubMed  Google Scholar 

  • Ferreri AJ, Viale E, Guidoboni M, et al. Clinical implications of hepatitis C virus infection in MALT-type lymphoma of the ocular adnexa. Ann Oncol. 2006c;17:769–72.

    Article  CAS  PubMed  Google Scholar 

  • Fox JG, Beck P, Dangler CA, et al. Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophy. Nat Med. 2000;6:536–42.

    Article  CAS  PubMed  Google Scholar 

  • Grulich AE, Li Y, McDonald AM, et al. Decreasing rates of Kaposi’s sarcoma and non-Hodgkin’s lymphoma in the era of potent combination anti-retroviral therapy. AIDS. 2001;15:629–33.

    Article  CAS  PubMed  Google Scholar 

  • Gupta N, Sachdev R, Tandon R. Ocular surface squamous neoplasia in xeroderma pigmentosum: clinical spectrum and outcome. Graefes Arch Clin Exp Ophthalmol. 2011;249:1217–21.

    Article  PubMed  Google Scholar 

  • Halbert CL, Demers GW, Galloway DA. The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cells. J Virol. 1992;66:2125–34.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Helt AM, Galloway DA. Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins. Carcinogenesis. 2003;24:159–69.

    Article  CAS  PubMed  Google Scholar 

  • Hirst LW, Axelsen RA, Schwab I. Pterygium and associated ocular surface squamous neoplasia. Arch Ophthalmol. 2009;127:31–2.

    Article  PubMed  Google Scholar 

  • Kestelyn P, Stevens AM, Ndayambaje A, Hanssens M. Perre van de P: HIV and conjunctival malignancies. Lancet. 1990;336:51–2.

    Article  CAS  PubMed  Google Scholar 

  • Macarez R, Bossis S, Robinet A, et al. Conjunctival epithelial neoplasias in organ transplant patients receiving cyclosporine therapy. Cornea. 1999;18:495–7.

    Article  CAS  PubMed  Google Scholar 

  • Manns MP, McHutchison JG, Gordon SC, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa- 2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet. 2001;358:958–65.

    Article  CAS  PubMed  Google Scholar 

  • McDonnell JM, McDonnell PJ, Mounts P, Wu TC, Green WR. Demonstration of papillomavirus capsid antigen in human conjunctival neoplasia. Arch Ophthalmol. 1986;104:1801–5.

    Article  CAS  PubMed  Google Scholar 

  • Midena E, Angeli CD, Valenti M, et al. Treatment of conjunctival squamous cell carcinoma with topical 5- fluorouracil. Br J Ophthalmol. 2000;84:268–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mikropoulos D, Mavrikakis I, Ziakas NG, Konstas AG, Boboridis KG. Kaposi’s sarcoma of the Bulbar Conjunctiva in an immunocompetent patient. Case Rep Ophthalmol. 2011;2(2):193–7.

    Article  PubMed  PubMed Central  Google Scholar 

  • Morgenstern KE, Givan J, Wiley LA. Long-term administration of topical interferon alfa-2beta in the treatment of conjunctival squamous papilloma. Arch Ophthalmol. 2003;121:1052–3.

    Article  PubMed  Google Scholar 

  • Newton R, Ferlay J, Reeves G, Beral V, Perkin DM. Incidence of squamous cell carcinoma of the eye increases with increasing levels of ambient solar ultraviolet radiation. Lancet. 1996;2:1450–1.

    Article  Google Scholar 

  • Palazzi MA, Erwenne CM, Villa LL. Detection of human papillomavirus in epithelial lesions of the conjunctiva. Sao Paulo Med J. 2000;118:125–30.

    Article  CAS  PubMed  Google Scholar 

  • Peralta-Zaragoza O, Bermu ́ dez-Morales V, Gutie ́rrez- Xicotencat lL, et al. E6 and E7 oncoproteins from human papillomavirus type 16 induce activation of human trans-forming growth factor beta1 promoter throughout Sp1 recognition sequence. Viral Immunol. 2006;19:468–80.

    Article  CAS  PubMed  Google Scholar 

  • Porges Y, Groisman GM. Prevalence of HIV with conjunctival squamous cell neoplasia in an African provincial hospital. Cornea. 2003;22:1–4.

    Article  PubMed  Google Scholar 

  • Restelli M, Grinstein S, Gattuso P, Preciado MV, Brunzini MA, Zarate J, Mosquera JM, Gould VE. Immunolocalization of the Epstein-Barr nuclear antigen-1 in conjunctival squamous carcinomas and dysplasias. Hum Pathol. 2005;36(4):325–9.

    Article  CAS  PubMed  Google Scholar 

  • Scott IU, Karp CL, Nuovo GJ. Human papillomavirus 16 and 18 expression in conjunctival intraepithelial neoplasia. Ophthalmology. 2002;109:542–7.

    Article  PubMed  Google Scholar 

  • Shelil AE, Shields CL, Shields JA, et al. Aggressive conjunctival squamous cell carcinoma in a patient following liver transplantation. Arch Ophthalmol. 2003;121:280–2.

    Article  PubMed  Google Scholar 

  • Simbiri KO, Robertson ES. Characterization of the OSSN Microbiome in HIV-1 Infected Patients. Cancer Clin Oncol. 2012;1:1.

    Google Scholar 

  • Simbiri KO, Murakami M, Feldman M, Steenhoff AP. Multiple oncogenic viruses identified in Ocular surface squamous neoplasia in HIV-1 patients. Inf Agent Cancer. 2010;5:6.

    Article  CAS  Google Scholar 

  • Song S, Gulliver GA, Lambert PF. Human papillomavirus type 16 E6 and E7 oncogenes abrogate radiation-induced DNA damage responses in vivo through p53-dependent and p53-independent pathways. Proc Natl Acad Sci U S A. 1998;95:2290–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Spitzer MS, Batumba NH, Chirambo T, Bartz-Schmidt KU. Ocular surface squamous neoplasia as the first apparent manifestation of HIV infection in Malawi. Clin Experiment Ophthalmol. 2008;36:422–5.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Kenneth O. Simbiri & Erle S. Robertson

Authors
  1. Kenneth O. Simbiri
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  2. Erle S. Robertson
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Correspondence to Kenneth O. Simbiri .

Editor information

Editors and Affiliations

  1. Department of Cell and Molecular Biology, Northwestern University, Robert H. Lurie Medical Research Center, Chicago, IL, USA

    Thomas J. Hope

  2. VA San Diego Healthcare System and University of California San Diego, La Jolla, CA, USA

    Douglas D. Richman

  3. Department of Medicine, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA

    Mario Stevenson

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Simbiri, K.O., Robertson, E.S. (2018). Conjunctival Carcinoma. In: Hope, T.J., Richman, D.D., Stevenson, M. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7101-5_27

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  • DOI: https://doi.org/10.1007/978-1-4939-7101-5_27

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-7100-8

  • Online ISBN: 978-1-4939-7101-5

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