Definition
The introduction of highly active antiretroviral therapy in the mid-1990s, along with new infections in adults over the age of 50, has resulted in increasing numbers of adults over 50 living with HIV and surviving into the later stages of life. These adults face a new set of challenges and threats to their health from cardiovascular disease and cancer as well as neurocognitive disease, bone disease, and frailty. In this chapter we describe the epidemiology of common chronic illnesses in the aging HIV population, as well as their relation to the HIV virus and traditional risk factors. Means to prevent, predict, and treat these conditions in the HIV-positive population are an area of ongoing study by HIV clinicians and researchers.
Introduction
Biologically, aging is a consequence of the rate at which an organism accumulates random damage and its ability to subsequently perform repairs in responding to these insults (Brothers and Rockwood 2014). The aging process is more...
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References
Aberg JA, et al. Primary care guidelines for the management of persons infected with HIV: 2013 update by the HIV Medicine Association of the Infectious Diseases Society of America. Clin Infect Dis. 2014;58(1):1–10.
AIDS Clinical Trials Group Network. REPRIEVE: Randomized Trial to Prevent Vascular Events in HIV. National Institutes of Health 2014 [cited 2015 June 29]; Available from: http://reprievetrial.org/our-team/nih/.
AIDSInfo. 2015; Available from: http://www.unaids.org/en/dataanalysis/datatools/aidsinfo/
Ali MK, et al. HIV and metabolic, body, and bone disorders: what we know from low- and middle-income countries. J Acquir Immune Defic Syndr. 2014;67 Suppl 1:S27–39.
Althoff KN, et al. Age, comorbidities, and AIDS predict a frailty phenotype in men who have sex with men. J Gerontol A Biol Sci Med Sci. 2014;69(2):189–98.
American Cancer Society. What are the key statistics about Kaposi sarcoma? Learn About Cancer 2014 [cited 2015 June 29]; Available from: http://www.cancer.org/cancer/kaposisarcoma/detailedguide/kaposi-sarcoma-what-is-key-statistics.
Aviles, C. and S. McGreevey. Can statin treatment cut cardiovascular risk in HIV-infected patients? Massachusetts General Hospital 2014 [cited 2015 June 29]; Available from: http://www.massgeneral.org/about/pressrelease.aspx?id=1755
Bhavan KP, Kampalath VN, Overton ET. The aging of the HIV epidemic. Curr HIV/AIDS Rep. 2008;5(3):150–8.
Brothers TD, Rockwood K. Biologic aging, frailty, and age-related disease in chronic HIV infection. Curr Opin HIV AIDS. 2014;9(4):412–8.
Cherner M, et al. Effects of HIV-1 infection and aging on neurobehavioral functioning: preliminary findings. AIDS. 2004;18 Suppl 1:S27–34.
Currier JS, et al. Epidemiological evidence for cardiovascular disease in HIV-infected patients and relationship to highly active antiretroviral therapy. Circulation. 2008;118(2):e29–35.
Deeks SG. Immune dysfunction, inflammation, and accelerated aging in patients on antiretroviral therapy. Top HIV Med. 2009;17(4):118–23.
Effros RB, et al. Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions. Clin Infect Dis. 2008;47(4):542–53.
Esser S, et al. Prevalence of cardiovascular diseases in HIV-infected outpatients: results from a prospective, multicenter cohort study. Clin Res Cardiol. 2013;102(3):203–13.
Friis-Moller N, et al. Predicting the risk of cardiovascular disease in HIV-infected patients: the data collection on adverse effects of anti-HIV drugs study. Eur J Cardiovasc Prev Rehabil. 2010;17(5):491–501.
Gannon P, Khan MZ, Kolson DL. Current understanding of HIV-associated neurocognitive disorders pathogenesis. Curr Opin Neurol. 2011;24(3):275–83.
Heaton RK, et al. HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. J Neurovirol. 2011;17(1):3–16.
National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention. CDC Fact Sheet: HIV Among People Aged 50 and Older. Centers for Disease Control and Prevention 2015 [cited 2015 June 29]; Available from: http://www.cdc.gov/hiv/pdf/group/age/olderamericans/HIV-Older-Americans-fact-sheet-508.pdf.
Hulten E, et al. HIV positivity, protease inhibitor exposure and subclinical atherosclerosis: a systematic review and meta-analysis of observational studies. Heart. 2009;95(22):1826–35.
Pathai S, et al. Is HIV a model of accelerated or accentuated aging? J Gerontol A Biol Sci Med Sci. 2014;69(7):833–42.
Rubinstein PG, Aboulafia DM, Zloza A. Malignancies in HIV/AIDS: from epidemiology to therapeutic challenges. AIDS. 2014;28(4):453–65.
Sabin CA. Do people with HIV infection have a normal life expectancy in the era of combination antiretroviral therapy? BMC Med. 2013;11:251.
Walker Harris V, Brown TT. Bone loss in the HIV-infected patient: evidence, clinical implications, and treatment strategies. J Infect Dis. 2012;205 Suppl 3:S391–8.
Womack JA, et al. Physiologic frailty and fragility fracture in HIV-infected male veterans. Clin Infect Dis. 2013;56(10):1498–504.
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Rao, S., Lambert, C., Moanna, A., Ali, M.K. (2018). Elderly: Epidemiology of HIV/AIDS. In: Hope, T.J., Richman, D.D., Stevenson, M. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7101-5_236
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DOI: https://doi.org/10.1007/978-1-4939-7101-5_236
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