Definition
Diffuse large B-cell lymphoma (DLBCL) is an AIDS-defining, aggressive lymphoid neoplasm in which normal lymph node architecture is replaced by sheets of large, atypical lymphoid cells. It is thought to arise from mature B cells and is comprised of large, noncleaved centroblasts and immunoblasts with abundant cytoplasm and prominent nucleoli. As the most common form of non-Hodgkin lymphoma (NHL) in both HIV-positive and HIV-negative individuals, there is an increasing appreciation of its morphologic, genetic, and biologic heterogeneity.
Epidemiology and Risk Factors
DLBCL accounts for roughly 30% of all NHLs in the HIV-negative population. By comparison, up to 75% of systemic NHL subtypes in HIV-seropositive individuals are comprised of DLBCL or variants thereof (Cote et al. 1997). As a whole, standardized incident ratios for NHL in HIV-positive individuals have decreased over the last two decades from over 1,000 in the early 1990s to below 200 in the mid-2000s due to the...
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Gupta, N.K., Kaplan, L.D. (2018). Diffuse Large B-Cell Lymphoma. In: Hope, T.J., Richman, D.D., Stevenson, M. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7101-5_10
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DOI: https://doi.org/10.1007/978-1-4939-7101-5_10
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