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Anaphylaxis and Anaphylactoid Reactions

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Family Medicine

Abstract

Anaphylaxis is an acute, potentially life-threatening, multisystem syndrome that is characterized by the release of mast cell- and basophil-derived mediators into the circulation after exposure to an antigen [1]. Traditionally, anaphylaxis was used to describe immunoglobulin E (IgE)-mediated reactions while “anaphylactoid” was used to describe non-IgE-mediated reactions. Anaphylaxis and anaphylactoid reactions are clinically indistinguishable and the World Allergy Organization recently suggested that “anaphylactoid reaction” be eliminated, with anaphylaxis divided into immunologic and non-immunologic reactions [2].

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References

  1. Sampson HA, Munoz-Furlong A, Campbell RL, et al. Second symposium on the definition and management of anaphylaxis: summary report – Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium. J Allergy Clin Immunol. 2006;117(2):391–7.

    Article  PubMed  Google Scholar 

  2. Johansson SG, Bieber T, Dahl R, et al. Revised nomenclature for allergy for global use: report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol. 2004;113(5):832–6.

    Article  CAS  PubMed  Google Scholar 

  3. Lieberman P, Camargo Jr CA, Bohlke K, et al. Epidemiology of anaphylaxis: findings of the American College of Allergy, Asthma and Immunology Epidemiology of Anaphylaxis Working Group. Ann Allergy Asthma Immunol. 2006;97(5):596–602.

    Article  PubMed  Google Scholar 

  4. Shen Y, Li L, Grant J, et al. Anaphylactic deaths in Maryland (United States) and Shanghai (China): a review of forensic autopsy cases from 2004 to 2006. Forensic Sci Int. 2009;186(1–3):1.

    Article  PubMed  Google Scholar 

  5. Lieberman P, Nicklas RA, Oppenheimer J, et al. The diagnosis and management of anaphylaxis practice parameter: 2010 update. J Allergy Clin Immunol. 2010;126(3):477–80.e1-42.

    Article  PubMed  Google Scholar 

  6. Gelincik A, Demirturk M, Yilmaz E, et al. Anaphylaxis in a tertiary adult allergy clinic: a retrospective review of 516 patients. Ann Allergy Asthma Immunol. 2013;110(2):96–100.

    Article  PubMed  Google Scholar 

  7. Beyer K, Eckermann O, Hompes S, et al. Anaphylaxis in an emergency setting-elicitors, therapy and incidence of severe allergic reactions. Allergy. 2012;67:1451–6.

    Article  CAS  PubMed  Google Scholar 

  8. Lee S, Hess EP, Nestler DM, et al. Antihypertensive use is associated with increased organ system involvement and hospitalization in emergency department patients with anaphylaxis. J Allergy Clin Immunol. 2013;131(4):1103–8.

    Article  PubMed  Google Scholar 

  9. Simons FE, Ardusso LR, Bilò MB, World Allergy Organization, et al. 2012 update: World Allergy Organization guidelines for the assessment and management of anaphylaxis. Curr Opin Allergy Clin Immunol. 2012;12(4):389–99.

    Article  PubMed  Google Scholar 

  10. Simons FE, Ardusso LR, Bilò MB, World Allergy Organization, et al. World Allergy Organization guidelines for the assessment and management of anaphylaxis. World Allergy Organ J. 2011;4(2):13–37.

    Article  PubMed Central  PubMed  Google Scholar 

  11. Sampson HA. Utility of food-specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol. 2001;107(5):891–6.

    Article  CAS  PubMed  Google Scholar 

  12. Braganza SC, Acworth JP, McKinnon DR, et al. Pediatric emergency department anaphylaxis: different patterns from adults. Arch Dis Child. 2006;91:159–63.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  13. Bilo BM, Bonifazi F. Epidemiology of insect-venom anaphylaxis. Curr Opin Allergy Clin Immunol. 2008;8:330–7.

    Article  PubMed  Google Scholar 

  14. Park M, Markus P, Matesic D, Li JT. Safety and effectiveness of a preoperative allergy clinic in decreasing vancomycin use in patients with a history of penicillin allergy. Ann Allergy Asthma Immunol. 2006;97:681.

    Article  CAS  PubMed  Google Scholar 

  15. Nokleby H. Vaccination and anaphylaxis. Curr Allergy Asthma Rep. 2006;6(1):9–13.

    Article  CAS  PubMed  Google Scholar 

  16. Pumphrey RS. Lessons for management of anaphylaxis from a study of fatal reactions. Clin Exp Allergy. 2000;30(8):1144–50.

    Article  CAS  PubMed  Google Scholar 

  17. Lin RY, Curry A, Pesola GR, et al. Improved outcomes in patients with acute allergic syndromes who are treated with combined H1 and H2 antagonists. Ann Emerg Med. 2000;36(5):462–8.

    Article  CAS  PubMed  Google Scholar 

  18. Runge JW, Martinez JC, Caravati EM, et al. Histamine antagonists in the treatment of acute allergic reactions. Ann Emerg Med. 1992;21(3):237–42.

    Article  CAS  PubMed  Google Scholar 

  19. Lieberman P. Biphasic anaphylactic reactions. Ann Allergy Asthma Immunol. 2005;95(3):217–26.

    Article  PubMed  Google Scholar 

  20. Tramer MR, von Elm E, Loubeyre P, Hauser C. Pharmacological prevention of serious anaphylactic reactions due to iodinated contrast media: systematic review. BMJ. 2006;333(7570):675.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  21. Greenberger PA, Patterson R. The prevention of immediate generalized reactions to radiocontrast media in high-risk patients. J Allergy Clin Immunol. 1991;87(4):867–72.

    Article  CAS  PubMed  Google Scholar 

  22. Dzingina M, Stegenga H, Heath M, et al. Assessment and referral after emergency treatment of a suspected anaphylactic episode: summary of NICE guidance. BMJ. 2011;343:d7595.

    Article  CAS  PubMed  Google Scholar 

  23. Hayman GR, Bansal JA, Bansal AS. Knowledge about using auto-injectable adrenaline: review of patients’ case notes and interviews with general practitioners. BMJ. 2003;327(7427):1328.

    Article  PubMed Central  PubMed  Google Scholar 

  24. Stecher D, Bulloch B, Sales J, et al. Epinephrine auto-injectors: is needle length adequate for delivery of epinephrine intramuscularly? Pediatrics. 2009;124(1):65–70.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Family and Community Medicine, Saint Louis University School of Medicine, 180 S. Third St., Suite 400, 62220, Belleville, IL, USA

    Cole R. Taylor

  2. SLU/USAF Scott Family Medicine Residency, St. Louis University School of Medicine, Belleville, IL, 62260, USA

    Wesley Carr

  3. Department of Family Medicine, St. Louis University School of Medicine, Belleville, IL, 62260, USA

    Sarah Gebauer

Authors
  1. Cole R. Taylor
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  2. Wesley Carr
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  3. Sarah Gebauer
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Corresponding author

Correspondence to Cole R. Taylor .

Editor information

Editors and Affiliations

  1. Department of Family Medicine, University of Nebraska, Omaha, Nebraska, USA

    Paul Paulman

  2. Virginia Beach, Virginia, USA

    Robert Taylor

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© 2015 Springer International Publishing Switzerland (outside the USA)

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Taylor, C.R., Carr, W., Gebauer, S. (2015). Anaphylaxis and Anaphylactoid Reactions. In: Paulman, P., Taylor, R. (eds) Family Medicine. Springer, Cham. https://doi.org/10.1007/978-1-4939-0779-3_39-1

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  • DOI: https://doi.org/10.1007/978-1-4939-0779-3_39-1

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  • Publisher Name: Springer, Cham

  • Online ISBN: 978-1-4939-0779-3

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