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Nuclear Import: HIV-1 Goes NUPs

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Encyclopedia of AIDS

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Definition

A key feature of human immunodeficiency virus type 1 (HIV-1) and other lentiviruses is their ability to traverse an intact nuclear envelope and productively infect nondividing cells. The nuclear import mechanisms of HIV-1 appear to involve interactions with several nucleoporin members, the constituent building blocks of nuclear pore complexes that span across the nuclear envelope.

Transport Pathways Between Nuclear and Cytoplasmic Compartments

Eukaryotic cells segregate their genomic information from the cytoplasmic milieu by sequestering the genome within the nuclear envelope, thereby defining the boundaries of the nuclear and cytoplasmic compartments of the cell. The presence of the nuclear envelope necessitates that eukaryotic cells maintain a continuous exchange of proteins and other macromolecules between these distinct cellular compartments to sustain proper cellular function. For example, transcription factors must reach their appropriate gene targets in the nucleus,...

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Author notes

    Authors and Affiliations

    1. Division of Biology, California Institute of Technology, Pasadena, CA, 91125, USA

      Cora L. Woodward

    2. Department of Molecular and Medical Pharmacology, UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, CA, 90095, USA

      Jonathan Wu & Samson A. Chow

    Authors
    1. Cora L. Woodward
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    2. Jonathan Wu
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    3. Samson A. Chow
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    Corresponding author

    Correspondence to Samson A. Chow .

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    Editors and Affiliations

    1. Dept. Cell & Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

      Thomas J. Hope

    2. Office of Graduate and Postdoctoral Studies, University of Miami, Miller School of Medicine, Miami, Florida, USA

      Mario Stevenson

    3. University of California, San Diego Dept. Pathology, La Jolla, California, USA

      Douglas Richman

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    Woodward, C.L., Wu, J., Chow, S.A. (2013). Nuclear Import: HIV-1 Goes NUPs. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_85-1

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    • DOI: https://doi.org/10.1007/978-1-4614-9610-6_85-1

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    • Online ISBN: 978-1-4614-9610-6

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