Definition
Viruses in general and HIV in particular have a limited genetic content. To accomplish their life cycle, lentiviruses make therefore use of host proteins, the so-called cellular cofactors, to complement the limited set of viral proteins carried in the viral particle. Interactions between host cell and viral proteins during different stages of lentiviral infection can provide attractive new antiviral targets (see entry Cellular Cofactors as HIV Drug Targets). The interaction between HIV envelope proteins and the CD4 receptor and either CXCR4 or CCR5 coreceptor is the best known virus-host interaction (see entry CXCR4, Coreceptors AND see Attachment/Binding). This interaction resulted in the development of the HIV fusion inhibitors enfuvirtide (targeting GP41) and maraviroc (targeting CCR5-GP120 interaction). Other host proteins that have been put forward as potential drug targets are DDX3 (see entry DDX3, cofactors and RNA export) and cofactors of HIV integration and nuclear...
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Taltynov, O., De Rijck, J., Debyser, Z. (2013). Identification and Validation of HIV Cofactors. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_82-1
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DOI: https://doi.org/10.1007/978-1-4614-9610-6_82-1
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