Definition
Despite the highly evolved and complex nature of HIV-1, it is still merely an obligate parasite. Thus, the HIV-1 replication cycle is completely dependent on host cellular proteins, lipids, and nucleic acids, herein defined as “cofactors.” HIV-1 advantageously usurps host cellular cofactors to facilitate a number of steps throughout the viral replication cycle. For example, HIV-1 fusion and entry are mediated by the major receptor, CD4, and coreceptors, CCR5 or CXCR4 (Fusion). Upon entry into the cell, HIV-1 reverse transcription is primed by cellular tRNALys3. Integration of the newly synthesized double-stranded viral DNA into the target cell genome is promoted by a cellular integrase-binding protein known as lens epithelium-derived growth factor (LEDGF/p75). The focus of this chapter will be to describe host cellular cofactors required late in the HIV-1 replication cycle, specifically, during viral assembly, budding, and release.
HIV-1 Gag Proteins Constitute the Virus...
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Kuo, L.S., Freed, E.O. (2013). HIV-1 Assembly Cofactors. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_75-1
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DOI: https://doi.org/10.1007/978-1-4614-9610-6_75-1
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