Encyclopedia of AIDS

Living Edition
| Editors: Thomas J. Hope, Douglas Richman, Mario Stevenson

Role of Histone Deacetylases 1 and Yin Yang 1 Protein in Proviral Latency

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-9610-6_73-1

Definition

HDAC1 is a member of the HDAC family of proteins, whereas YY1 is a ubiquitously expressed transcriptional factor with both repressive and activating functions. Cooperatively, these two proteins have been shown to repress transcription from the viral LTR promoter and have been proposed to contribute to the state of post-integration latency.

Introduction

After the integration into the host cell chromatin, the HIV-1 genome can be reversibly silenced through multiple mechanisms, establishing a state of post-integration latency. Although different posttranscriptional mechanisms participate in maintaining the latent state, it is usually a block at the transcriptional level that gives a major contribution to the establishment of latency (Lusic and Giacca 2014).

The establishment of latency, according to a now prevailing theory, foresees the infection of activated CD4+T cells prior to their natural reversion to a quiescent memory state; this is also compatible with the finding...

Keywords

Long Terminal Repeat Viral Promoter Long Terminal Repeat Promoter Proviral Latency Chicken Ovalbumin Upstream Promoter Transcription Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Infectious Diseases, Integrative VirologyUniversity Hospital Heidelberg and German Centre for Infection ResearchHeidelbergGermany