Role of Histone Deacetylases 1 and Yin Yang 1 Protein in Proviral Latency
HDAC1 is a member of the HDAC family of proteins, whereas YY1 is a ubiquitously expressed transcriptional factor with both repressive and activating functions. Cooperatively, these two proteins have been shown to repress transcription from the viral LTR promoter and have been proposed to contribute to the state of post-integration latency.
After the integration into the host cell chromatin, the HIV-1 genome can be reversibly silenced through multiple mechanisms, establishing a state of post-integration latency. Although different posttranscriptional mechanisms participate in maintaining the latent state, it is usually a block at the transcriptional level that gives a major contribution to the establishment of latency (Lusic and Giacca 2014).
The establishment of latency, according to a now prevailing theory, foresees the infection of activated CD4+T cells prior to their natural reversion to a quiescent memory state; this is also compatible with the finding...
KeywordsLong Terminal Repeat Viral Promoter Long Terminal Repeat Promoter Proviral Latency Chicken Ovalbumin Upstream Promoter Transcription Factor
- Lusic M, Giacca M (2014) Regulation of HIV-1 latency by chromatin structure and nuclear architecture. J Mol Biol 427(3):688–694. doi: 10.1016/j.jmb.2014.07.022. [Epub ahead of print]Google Scholar