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Role of LEDGF/p75 in Cell Biology and Disease Pathogenesis

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Encyclopedia of AIDS

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Definition

LEDGF/p75 is a chromatin-associated cellular protein with roles in embryonic development, transcriptional regulation, and cell survival that has been implicated in autoimmunity, carcinogenesis, and HIV replication. A key feature is its ability to act as a molecular adapter to tether proteins to the chromatin. Recent studies have uncovered its role in leukemia, cell survival, and DNA repair. Biophysical characterization of its dynamic interaction with chromatin sheds light on how a single protein can exert so many functions. The function of LEDGF/p75 in HIV replication has been further elaborated, and the insight in the interaction between LEDGF/p75 and IN has resulted in a new class of inhibitors (LEDGINs) blocking HIV replication.

Introduction

LEDGF/p75 has been identified on four different occasions in association with transcriptional regulation, cell survival, autoimmunity, or virology (Ge et al. 1998; Singh et al. 2000; Ochs et al. 2000; Cherepanov et al. 2003)....

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References

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Authors and Affiliations

  1. Laboratory for Molecular Virology and Gene Therapy, KU Leuven, 3000, Leuven, Flanders, Belgium

    Rik Schrijvers & Zeger Debyser

Authors
  1. Rik Schrijvers
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  2. Zeger Debyser
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Correspondence to Rik Schrijvers .

Editor information

Editors and Affiliations

  1. Dept. Cell & Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

    Thomas J. Hope

  2. Office of Graduate and Postdoctoral Studies, University of Miami, Miller School of Medicine, Miami, Florida, USA

    Mario Stevenson

  3. University of California, San Diego Dept. Pathology, La Jolla, California, USA

    Douglas Richman

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Schrijvers, R., Debyser, Z. (2013). Role of LEDGF/p75 in Cell Biology and Disease Pathogenesis. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_72-1

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  • DOI: https://doi.org/10.1007/978-1-4614-9610-6_72-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-9610-6

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