Definition
Assembly is the process whereby the components necessary for transmission of HIV to a new cell come together to form a viral particle or virion. These principal components are the proteins Gag and GagPol, the envelope glycoproteins, the viral genome, and some of the HIV accessory proteins. Assembly occurs on cellular membranes; immature virions bud through the cell membrane and are released by the action of host-cell cofactors recruited by Gag. Maturation, which occurs during or immediately followingbudding, involves the cleavage of Gag and GagPol by HIV protease and subsequent modification of the internal structure of the virion necessary for infectivity. Assembly can be considered complete once an infectious virion has been generated.
Although AIDS is caused by both HIV-1 and HIV-2, the majority of human infections and the majority of research involve HIV-1. This review will therefore deal almost exclusively with HIV-1; however, it is probable that HIV-2 behaves similarly...
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References
Balasubramaniam M, Freed EO. New insights into HIV assembly and trafficking. Physiology (Bethesda). 2011;26(4):236–51.
Benaroch P et al. HIV-1 assembly in macrophages. Retrovirology. 2010;7:29.
Freed EO, Martin MA. HIVs and their replication. In: Knipe DM, Howley PM, editors. Fields virology. Philadelphia: Lippincott, Williams, and Wilkins; 2012.
Fujita M et al. SAMHD1-dependent and -independent functions of HIV-2/SIV Vpx protein. Frontiers Microbiol. 2012;3:297.
Ganser-Pornillos BK, Yeager M, Sundquist WI. The structural biology of HIV assembly. Curr Opin Struct Biol. 2008;18(2):203–17.
Hill M, Tachedjian G, Mak J. The packaging and maturation of the HIV-1 Pol proteins. Curr HIV Res. 2005;3(1):73–85.
Lu K, Heng X, Summers MF. Structural determinants and mechanism of HIV-1 genome packaging. J Mol Biol. 2011;410(4):609–33.
Martin-Serrano J, Neil SJD. Host factors involved in retroviral budding and release. Nat Rev Microbiol. 2011;9(7):519–31.
Mateu MG. The capsid protein of human immunodeficiency virus: intersubunit interactions during virus assembly. FEBS J. 2009;276(21):6098–109.
Morita E. Differential requirements of mammalian ESCRTs in multivesicular body formation, virus budding and cell division. FEBS J. 2012;279(8):1399–406.
Ott DE. Cellular proteins detected in HIV-1. Rev Med Virol. 2008;18(3):159–75.
Postler TS, Desrosiers RC. The tale of the long tail: the cytoplasmic domain of HIV-1 gp41. J Virol. 2012;87(1):2–15.
Sundquist WI, Kräusslich H-G. HIV-1 assembly, budding, and maturation. Cold Spring Harb Perspect Med. 2012;2(7):a006924.
Waheed AA, Freed EO. HIV type 1 Gag as a target for antiviral therapy. AIDS Res Hum Retroviruses. 2012;28(1):54–75.
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Tedbury, P.R., Freed, E.O. (2013). Virus Assembly. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_55-1
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DOI: https://doi.org/10.1007/978-1-4614-9610-6_55-1
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