The Antibody Response to HIV-2
Neutralizing antibodies (nAbs) inhibit or neutralize the infectiveness of a virus or bacteria. Broadly neutralizing antibodies (bNAbs) are neutralizing antibodies, which are able to neutralize multiple strains of HIV. Antibody-dependent complement-mediated inactivation (ADCMI) is a cell mediated mechanism whereby an effector cell actively lyses a target cell, which has been bound by a specific antibody. It is one of the mechanisms through which antibodies control HIV infection. Compared to HIV-1-infected patients, more HIV-2-infected subjects develop bNAbs and have a greater magnitude of the intratype antiviral activity of ADCMI.
Many HIV-2-infected patients are able to control the progression of the infection more effectively than most HIV-1-infected subjects. In many HIV-2-infected patients, the viral load remains below limits of detection and CD4 T-cell counts remain normal; therefore, the disease progression may take decades (Marlink et al. 1994). Although...
- Bailey JR, Lassen KG, Yang HC, Quinn TC, Ray SC, Blankson JN, Siliciano RF. Neutralizing antibodies do not mediate suppression of human immunodeficiency virus type1 in elite suppressors or selection of plasma virus variants in patients on highly active antiretroviral therapy. J Virol 2006;80:4758–70.Google Scholar
- Marcelino JM, Borrego P, Fau-Rocha C, Rocha C, Fau-Barroso H, Barroso H, Fau-Quintas A, Quintas A, Fau-Novo C, Novo C, Fau-Taveira N, et al. Potent and broadly reactive HIV-2 neutralizing antibodies elicited by a vaccinia virus vector prime-C2V3C3 polypeptide boost immunization strategy. J Virol. 2010;84:12429–36.PubMedCentralCrossRefPubMedGoogle Scholar
- Ozkaya Sahin G, Holmgren B, da Silva Z, Nielsen J, Nowroozalizadeh S, Esbjornsson J, Månsson F, Andersson S, Norrgren H, Aaby P, Jansson M, Fenyä EM. Potent intratype neutralizing activity distinguishes human immunodeficiency virus type 2 (HIV-2) from HIV-1. J Virol. 2012;86:961–71.Google Scholar
- Palmer E, Martin ML, Goldsmith C, Switzer W. Ultrastructure of human immunodeficiency virus type 2. J Gen Virol 1988;69:1425–9Google Scholar
- Thomas ER, Shotton C, Weiss RA, Clapham PR, McKnight A. CD4-dependent and CD4-independent HIV-2: consequences for neutralization. AIDS. 2003;17:291–300.Google Scholar