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The Antibody Response to HIV-2

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  • Bailey JR, Lassen KG, Yang HC, Quinn TC, Ray SC, Blankson JN, Siliciano RF. Neutralizing antibodies do not mediate suppression of human immunodeficiency virus type1 in elite suppressors or selection of plasma virus variants in patients on highly active antiretroviral therapy. J Virol 2006;80:4758–70.

    Google Scholar 

  • Barroso H, Taveira N. Evidence for negative selective pressure in HIV-2 evolution in vivo. Infect Genet Evol. 2005;5:239–46.

    Article  CAS  PubMed  Google Scholar 

  • Bjorling E, Chiodi F, Utter G, Norrby E. Two neutralizing domains in the V3 region in the envelope glycoprotein gp125 of HIV type 2. J Immunol. 1994;152:1952–9.

    CAS  PubMed  Google Scholar 

  • Cavaleiro R, Brunn GJ, Albuquerque AS, Victorino RM, Platt JL, Sousa AE. Monocyte-mediated T cell suppression by HIV-2 envelope proteins. Eur J Immunol. 2007;37:3435–44.

    Article  CAS  PubMed  Google Scholar 

  • Gordon SN, Klatt NR, Bosinger SE, Brenchley JM, Milush JM, Engram JC, et al. Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys. J Immunol. 2007;179:3026–34.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Huang ML, Essex M, Lee TH. Localization of immunogenic domains in the human immunodeficiency virus type 2 envelope. J Virol. 1991;65:5073–9.

    PubMed Central  CAS  PubMed  Google Scholar 

  • Huang CC, Tang M, Zhang MY, Majeed S, Montabana E, Stanfield RL, et al. Structure of a V3-containing HIV-1 gp120 core. Science. 2005;310:1025–8.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Kong R, Li H, Bibollet-Ruche F, Decker JM, Zheng NN, Gottlieb GS, et al. Broad and potent neutralizing antibody responses elicited in natural HIV-2 infection. J Virol. 2012;86:947–60.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Lin G, Bertolotti-Ciarlet A, Haggarty B, Romano J, Nolan KM, Leslie GJ, et al. Replication-competent variants of human immunodeficiency virus type 2 lacking the V3 loop exhibit resistance to chemokine receptor antagonists. J Virol. 2007;81:9956–66.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Marcelino JM, Nilsson C, Barroso H, Gomes P, Borrego P, Maltez F, et al. Envelope-specific antibody response in HIV-2 infection: C2V3C3-specific IgG response is associated with disease progression. AIDS. 2008;22:2257–65.

    Article  CAS  PubMed  Google Scholar 

  • Marcelino JM, Borrego P, Fau-Rocha C, Rocha C, Fau-Barroso H, Barroso H, Fau-Quintas A, Quintas A, Fau-Novo C, Novo C, Fau-Taveira N, et al. Potent and broadly reactive HIV-2 neutralizing antibodies elicited by a vaccinia virus vector prime-C2V3C3 polypeptide boost immunization strategy. J Virol. 2010;84:12429–36.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Marlink R, Kanki P, Thior I, Travers K, Eisen G, Siby T, et al. Reduced rate of disease development after HIV-2 infection as compared to HIV-1. Science. 1994;265:1587–90.

    Article  CAS  PubMed  Google Scholar 

  • Ozkaya Sahin G, Holmgren B, da Silva Z, Nielsen J, Nowroozalizadeh S, Esbjornsson J, Månsson F, Andersson S, Norrgren H, Aaby P, Jansson M, Fenyä EM. Potent intratype neutralizing activity distinguishes human immunodeficiency virus type 2 (HIV-2) from HIV-1. J Virol. 2012;86:961–71.

    Google Scholar 

  • Palmer E, Martin ML, Goldsmith C, Switzer W. Ultrastructure of human immunodeficiency virus type 2. J Gen Virol 1988;69:1425–9

    Google Scholar 

  • Ren X, Sodroski J, Yang X. An unrelated monoclonal antibody neutralizes human immunodeficiency virus type 1 by binding to an artificial epitope engineered in a functionally neutral region of the viral envelope glycoproteins. J Virol. 2005;79:5616–24.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Shi Y, Brandin E, Vincic E, Jansson M, Blaxhult A, Gyllensten K, et al. Evolution of human immunodeficiency virus type 2 coreceptor usage, autologous neutralization, envelope sequence and glycosylation. J Gen Virol. 2005;86:3385–96.

    Article  CAS  PubMed  Google Scholar 

  • Skar H, Borrego P, Wallstrom TC, Mild M, Marcelino JM, Barroso H, et al. HIV-2 genetic evolution in patients with advanced disease is faster than that in matched HIV-1 patients. J Virol. 2010;84:7412–5.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Thomas ER, Shotton C, Weiss RA, Clapham PR, McKnight A. CD4-dependent and CD4-independent HIV-2: consequences for neutralization. AIDS. 2003;17:291–300.

    Google Scholar 

  • van Gils MJ, Euler Z, Schweighardt B, Wrin T, Schuitemaker H. Prevalence of cross-reactive HIV-1-neutralizing activity in HIV-1-infected patients with rapid or slow disease progression. AIDS. 2009;23:2405–14.

    Article  PubMed  Google Scholar 

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Correspondence to Shokouh Makvandi-Nejad .

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Makvandi-Nejad, S. (2015). The Antibody Response to HIV-2. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_50-1

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  • DOI: https://doi.org/10.1007/978-1-4614-9610-6_50-1

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